SLC25A45 Antibody (C-6): sc-514755

SLC25A45 Antibody (C-6) is a mouse monoclonal IgM antibody that detects SLC25A45 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SLC25A45 antibody (C-6) is available as a non-conjugated antibody. SLC25A45, also known as solute carrier family 25 member 45, is a 288 amino acid multi-pass membrane protein that facilitates metabolite transport across the inner mitochondrial membrane. SLC25A45 maintains cellular energy metabolism and health by ensuring essential substrates are available for mitochondrial respiration and ATP production. SLC25A45 is expressed in various tissues and contains three Solcar repeats, characteristic of the SLC25 family of mitochondrial carriers. The human gene encoding SLC25A45 is located on chromosome 11, a region associated with several diseases, including Wilms′ tumors and WAGR syndrome, highlighting SLC25A45′s importance in normal physiology and disease states. Through alternative splicing, SLC25A45 produces four known isoforms, exhibiting functional diversity relevant in different biological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SLC25A45 Antibody (C-6) References:

1. The 11q terminal deletion disorder: a prospective study of 110 cases.  |  Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.  |  Kimura, K., et al. 2006. Genome Res. 16: 55-65. PMID: 16344560
3. Human chromosome 11 DNA sequence and analysis including novel gene identification.  |  Taylor, TD., et al. 2006. Nature. 440: 497-500. PMID: 16554811
4. KCNQ1 K+ channel-mediated cardiac channelopathies.  |  Loussouarn, G., et al. 2006. Methods Mol Biol. 337: 167-83. PMID: 16929947
5. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.  |  Haitina, T., et al. 2006. Genomics. 88: 779-790. PMID: 16949250
6. Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome.  |  Zehelein, J., et al. 2006. J Biol Chem. 281: 35397-403. PMID: 16987820
7. Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability.  |  Ataga, KI., et al. 2007. Br J Haematol. 139: 3-13. PMID: 17854302
8. The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.  |  Berger, AC., et al. 2007. J Cell Sci. 120: 3640-52. PMID: 17895371
9. Wilms tumour: prognostic factors, staging, therapy and late effects.  |  Kaste, SC., et al. 2008. Pediatr Radiol. 38: 2-17. PMID: 18026723

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLC25A45 Antibody (C-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SLC25A45 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLC25A45 Antibody (C-6) Specifications

Alternate Product Name: SLC25A45

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 187-201

Epitope Target: SLC25A45

Epitope Species: human

Product Reactivity/Detection: SLC25A45 isoforms 1-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SLC25A45 Antibody (C-6): P: Blocking Peptide