SBP-2 Antibody (2957C2a): sc-130639

SBP-2 Antibody (2957C2a) is a mouse monoclonal IgG1 antibody that detects SBP-2 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. SBP-2, or SECIS-binding protein 2, plays a crucial role in the translation of selenoproteins by specifically binding to the selenocysteine insertion sequence (SECIS) element found in the 3′ untranslated region of selenoprotein mRNAs. This interaction is vital for the proper decoding of the UGA codon as selenocysteine, which is essential for the synthesis of various selenoproteins that are involved in antioxidant defense and redox regulation. SBP-2 is predominantly located in the liver and testis, as well as in hepatoma cells, highlighting its importance in tissues with high metabolic activity. SBP-2′s ability to associate with ribosomal fractions underscores its role in facilitating the incorporation of selenocysteine into proteins, thereby influencing cellular functions related to oxidative stress response. Anti-SBP-2 antibody (2957C2a) is an invaluable tool for researchers studying the mechanisms of selenoprotein synthesis and the broader implications of selenium in human health.

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SBP-2 Antibody (2957C2a) References:

1. Meta-analysis of randomized controlled trials comparing telmisartan with losartan in the treatment of patients with hypertension.  |  Xi, GL., et al. 2008. Am J Hypertens. 21: 546-52. PMID: 18437146
2. The role of continuous positive airway pressure in blood pressure control for patients with obstructive sleep apnea and hypertension: a meta-analysis of randomized controlled trials.  |  Hu, X., et al. 2015. J Clin Hypertens (Greenwich). 17: 215-22. PMID: 25582849
3. Efficacy of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH): Systematic review and meta-analysis.  |  Labarca, G., et al. 2021. Sleep Med Rev. 58: 101446. PMID: 33607443
4. Seasonal Variation in Day-by-Day Home Blood Pressure Variability and Effect on Cardiovascular Disease Incidence.  |  Narita, K., et al. 2022. Hypertension. 79: 2062-2070. PMID: 35770661
5. The Association Between Smartphone App-Based Self-monitoring of Hypertension-Related Behaviors and Reductions in High Blood Pressure: Systematic Review and Meta-analysis.  |  Kassavou, A., et al. 2022. JMIR Mhealth Uhealth. 10: e34767. PMID: 35819830
6. Transurethral Renal Pelvic Denervation: A Feasibility Trial in Patients with Uncontrolled Hypertension.  |  Hering, D., et al. 2022. Hypertension. 79: 2787-2795. PMID: 36254733
7. Systolic blood pressure reduction with tirzepatide in patients with type 2 diabetes: insights from SURPASS clinical program.  |  Lingvay, I., et al. 2023. Cardiovasc Diabetol. 22: 66. PMID: 36964557
8. Chronic effect of resistance training on blood pressure in older adults with prehypertension and hypertension: A systematic review and meta-analysis.  |  Henkin, JS., et al. 2023. Exp Gerontol. 177: 112193. PMID: 37121334
9. Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program.  |  Azizi, M., et al. 2024. Circulation. 149: 747-759. PMID: 37883784
10. Effects of Cocoa Consumption on Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials.  |  Arisi, TOP., et al. 2024. Nutrients. 16: PMID: 38931273

The preferred SBP-2 antibody is SBP-2 Antibody (C-10): sc-393651.