Saccharocarcin A CAS: 158475-32-2
MF: C67H101NO20
MW: 1240.5
An unusual tetronic acid with inhibitory effects on gram positive bacteria.

Saccharocarcin A (CAS 158475-32-2)

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Anwendungen Saccharocarcin A is an unusual tetronic acid with inhibitory effects on gram positive bacteria
CAS Nummer: 158475-32-2
Reinheit: >95%
Molekulargewicht: 1240.5
Summenformel: C67H101NO20
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
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Saccharocarcin A is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin which has pronounced activity against Gram positive bacteria and Chlamydia trachomatis. Limited availability has restricted further investigation of this metabolite in the literature, however, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway.

Aggregatzustand :
Solid
Erhaltene Form :
Amycolatopsis
Löslichkeit :
Soluble in ethanol, methanol, DMSO, DMF, and water (limited).
LAGERUNG: :
Store at -20° C
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.

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