(S)-(−)-Indoline-2-carboxylic acid (CAS 79815-20-6)
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(S)-(−)-Indoline-2-carboxylic acid, also known as (−)-Indoline-2-carboxylic acid, is a catalyst for enantioselective cyclopropanations. (S)-(−)-Indoline-2-carboxylic acid, a naturally occurring compound, has garnered significant attention in medicinal chemistry due to its potential applications. This chiral molecule exists in two mirror image forms: the (+) and (−) forms, with the latter being the more active and studied one. Exploring its diverse properties, researchers have investigated its potential and ability to inhibit specific enzymes and modulate receptor activity has been thoroughly examined. Though the precise mechanism of action remains partly elusive, it is believed that (S)-(−)-Indoline-2-carboxylic acid acts as an enzyme inhibitor, especially targeting tyrosinase, while also influencing receptor activity. Moreover, its antioxidant properties are thought to play a role in scavenging free radicals and safeguarding cells against oxidative damage.
(S)-(−)-Indoline-2-carboxylic acid (CAS 79815-20-6) References
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- Purification, identification and characterization of an esterase with high enantioselectivity to (S)-ethyl indoline-2-carboxylate. | Zhang, YJ., et al. 2019. Biotechnol Lett. 41: 1223-1232. PMID: 31456128
- A Proline Mimetic for the Design of New Stable Secondary Structures: Solvent-Dependent Amide Bond Isomerization of (S)-Indoline-2-carboxylic Acid Derivatives. | Pollastrini, M., et al. 2021. J Org Chem. 86: 7946-7954. PMID: 34080867
- Semi-rational protein engineering of a novel esterase from Bacillus aryabhattai (BaCE) for resolution of (R,S)-ethyl indoline-2-carboxylate to prepare (S)-indoline-2-carboxylic acid. | Zhang, H., et al. 2022. Bioorg Chem. 120: 105602. PMID: 35065466
- A Unique and Stable Polyproline I Helix Sorted out from Conformational Equilibrium by Solvent Polarity. | Pollastrini, M., et al. 2022. J Org Chem. 87: 13715-13725. PMID: 36242553
- Direct enantioselective separation of clenbuterol by chiral HPLC in biological fluids. | Abou-Basha, LI. and Aboul-Enein, HY. 1996. Biomed Chromatogr. 10: 69-72. PMID: 8924729
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-(−)-Indoline-2-carboxylic acid, 1 g | sc-255553 | 1 g | $31.00 |