Rtn-1A Antibody (MON162): sc-58588

Rtn-1A Antibody (MON162) is a mouse monoclonal IgG1 antibody that detects Rtn-1A in mouse, rat, human, and hamster samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Rtn-1A, also known as neuroendocrine-specific protein A, plays a crucial role in the endoplasmic reticulum′s structure and function, which is vital for maintaining cellular homeostasis and facilitating protein synthesis and folding. Rtn-1A is primarily localized in the membranes of the endoplasmic reticulum, where Rtn-1A contributes to the shaping of the organelle and is involved in neuroendocrine secretion and membrane trafficking. Rtn-1A expression is particularly significant in lung cancer, serving as a reliable marker for neuroendocrine differentiation, with elevated levels in small cell lung carcinoma and carcinoid tumors. Additionally, Rtn-1A is produced in multiple isoforms through alternative splicing, which allows for functional diversity and adaptability in various cellular contexts. Anti-Rtn-1A antibody (MON162) is an essential tool for researchers investigating the role of reticulon proteins in neuroendocrine functions and their implications in cancer biology.

The preferred Rtn-1A antibody is Rtn-1A Antibody (Mon 160): sc-23880.