Rtn-1A Antibody (Mon 160): sc-23880
- Rtn-1A Antibody (Mon 160) is a mouse monoclonal IgG1 κ Rtn-1A antibody, cited in 4 publications, provided at 200 µg/ml
- raised against bacterially expressed Reticulon-1A (NSP-A) hybrid protein (beta-GAL-NSP-A 6-776)
- Rtn-1A Antibody (Mon 160) is recommended for detection of Rtn-1A of mouse, rat, human and hamster origin by WB, IP, IF and IHC(P)
- Anti-Rtn-1A Antibody (Mon 160) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Rtn-1A Antibody (Mon 160) for WB and IHC(P) applications. These reagents are now offered in bundles with Rtn-1A Antibody (Mon 160) (see ordering information below).
Rtn-1A Antibody (Mon 160) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rtn-1A protein of mouse, rat, human, and hamster origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). anti-Rtn-1A antibody (Mon 160) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rtn-1A, a member of the Reticulon family, plays a crucial role in the structure and function of the endoplasmic reticulum, where Rtn-1A is anchored through its C-terminal region. Rtn-1A is essential for maintaining the morphology of the endoplasmic reticulum and is involved in processes such as neuroendocrine secretion and membrane trafficking. The gene encoding Rtn-1 is located on human chromosome 14q23.1 and is expressed as three isoforms—Rtn-1A, Rtn-1B, and Rtn-1C—through alternative splicing. Notably, Rtn-1A serves as a reliable marker for neuroendocrine differentiation in lung cancer, as Rtn-1A is expressed in most small cell lung carcinoma and carcinoid tumors, making Rtn-1A a valuable tool for diagnostic purposes. Additionally, Rtn-1B exists in multiple forms, while Rtn-1C expression is strongly correlated with neuronal differentiation, highlighting the diverse roles of these proteins in cellular functions and their potential implications in cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rtn-1A Antibody (Mon 160) References:
- Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. | Moreira, EF., et al. 1999. Genomics. 58: 73-81. PMID: 10331947
- Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. | GrandPré, T., et al. 2000. Nature. 403: 439-44. PMID: 10667797
- Subcellular localization and supramolecular organization of neuroendocrine-specific protein B (NSP-B) in small cell lung cancer. | Senden, NH., et al. 1994. Eur J Cell Biol. 65: 341-53. PMID: 7720728
- NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis. | van de Velde, HJ., et al. 1994. Cancer Res. 54: 4769-76. PMID: 8062278
- Molecular cloning of a novel mouse gene with predominant muscle and neural expression. | Geisler, JG., et al. 1998. Mamm Genome. 9: 274-82. PMID: 9530622
- Neuronal differentiation is accompanied by NSP-C expression. | Hens, J., et al. 1998. Cell Tissue Res. 292: 229-37. PMID: 9560466
- cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons. | Roebroek, AJ., et al. 1998. Genomics. 51: 98-106. PMID: 9693037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rtn-1A Antibody (Mon 160) | sc-23880 | 200 µg/ml | $322.00 | |||
Rtn-1A Antibody (Mon 160): m-IgG Fc BP-HRP Bundle | sc-526624 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rtn-1A Antibody (Mon 160): m-IgG1 BP-HRP Bundle | sc-531997 | 200 µg Ab; 20 µg BP | $361.00 | |||
Rtn-1A Antibody (Mon 160) AC | sc-23880 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Rtn-1A Antibody (Mon 160) HRP | sc-23880 HRP | 200 µg/ml | $322.00 | |||
Rtn-1A Antibody (Mon 160) FITC | sc-23880 FITC | 200 µg/ml | $336.00 | |||
Rtn-1A Antibody (Mon 160) PE | sc-23880 PE | 200 µg/ml | $349.00 | |||
Rtn-1A Antibody (Mon 160) Alexa Fluor® 488 | sc-23880 AF488 | 200 µg/ml | $364.00 | |||
Rtn-1A Antibody (Mon 160) Alexa Fluor® 546 | sc-23880 AF546 | 200 µg/ml | $364.00 | |||
Rtn-1A Antibody (Mon 160) Alexa Fluor® 594 | sc-23880 AF594 | 200 µg/ml | $364.00 | |||
Rtn-1A Antibody (Mon 160) Alexa Fluor® 647 | sc-23880 AF647 | 200 µg/ml | $364.00 | |||
Rtn-1A Antibody (Mon 160) Alexa Fluor® 680 | sc-23880 AF680 | 200 µg/ml | $364.00 | |||
Rtn-1A Antibody (Mon 160) Alexa Fluor® 790 | sc-23880 AF790 | 200 µg/ml | $364.00 |