Rock-2 Antibody (30-J): sc-100425
- Rock-2 Antibody (30-J) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 100 µg/ml
- raised against recombinant Rock-2 of human origin
- recommended for detection of Rock-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- See Rock-2 (D-11): sc-398519 for Rock-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rock-2 Antibody (30-J). This work is in progress.
Rock-2 Antibody (30-J) is a mouse monoclonal IgG2b antibody that detects Rock-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rock-2, also known as Rho-associated coiled-coil containing protein kinase 2, plays a crucial role in regulating various cellular processes, including cell migration, proliferation, and apoptosis, by acting as a downstream effector of the Rho GTPase signaling pathway. Rock-2 (30-J) antibody helps researchers study Rock-2′s ability to modulate the actin cytoskeleton, which is essential for maintaining cell shape and facilitating movement. Additionally, Rock-2 is involved in the phosphorylation of myosin light chains, which is critical for muscle contraction and cellular tension. Understanding the function of Rock-2 is vital, as dysregulation of Rock-2 has been implicated in various diseases, including cancer and cardiovascular disorders. Anti-Rock-2 antibody (30-J) provides a reliable tool for researchers aiming to explore the intricate roles of Rock-2 in cellular dynamics and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rock-2 Antibody (30-J) References:
- ROCK-2 is associated with focal adhesion maturation during myoblast migration. | Goetsch, KP., et al. 2014. J Cell Biochem. 115: 1299-307. PMID: 24700588
- ROCK-2-selective targeting and its therapeutic outcomes. | Sharma, P. and Roy, K. 2020. Drug Discov Today. 25: 446-455. PMID: 31837997
- CSE-Derived H2S Inhibits Reactive Astrocytes Proliferation and Promotes Neural Functional Recovery after Cerebral Ischemia/Reperfusion Injury in Mice Via Inhibition of RhoA/ROCK2 Pathway. | Zhang, Y., et al. 2021. ACS Chem Neurosci. 12: 2580-2590. PMID: 34252278
- RhoA, ROCK-1, and ROCK-2 Gene Expression and Polymorphisms in Cholesteatoma Patients. | Görür, K., et al. 2021. J Int Adv Otol. 17: 530-535. PMID: 35177391
- Belumosudil with ROCK-2 inhibition: chemical and therapeutic development to FDA approval for the treatment of chronic graft-versus-host disease. | Ali, F. and Ilyas, A. 2022. Curr Res Transl Med. 70: 103343. PMID: 35339032
- Protection against Hypoxia-Reoxygenation Injury of Hippocampal Neurons by H2S via Promoting Phosphorylation of ROCK2 at Tyr722 in Rat Model. | Xue, M., et al. 2022. Molecules. 27: PMID: 35889443
- Protection of H2S against Hypoxia/Reoxygenation Injury in Rat Hippocampal Neurons through Inhibiting Phosphorylation of ROCK2 at Thr436 and Ser575. | Fang, F., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 37259366
- Effects of combined electroacupuncture and medication therapy on the RhoA/ROCK-2 signaling pathway in the striatal region of rats afflicted by cerebral ischemia. | Liu, M., et al. 2023. Brain Res Bull. 205: 110828. PMID: 38029846
- H2S protects rat cerebral ischemia-reperfusion injury by inhibiting expression and activation of hippocampal ROCK2 at the Thr436 and Ser575 sites. | Fang, F., et al. 2024. Eur J Pharmacol. 985: 177079. PMID: 39486769
- Hydrogen sulfide-mediated inhibition of ROCK2 exerts a vasoprotective effecton ischemic brain injury. | Chen, Y., et al. 2024. Am J Physiol Cell Physiol.. PMID: 39716722
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rock-2 Antibody (30-J) | sc-100425 | 100 µg/ml | $339.00 |