Reticulol CAS: 26246-41-3
MF: C11H10O5
MW: 222.2
An isocoumarin metabolite shown to inactivate topoisomerase I.

Reticulol (CAS 26246-41-3)

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Anwendungen Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I
CAS Nummer: 26246-41-3
Reinheit: >95%
Molekulargewicht: 222.2
Summenformel: C11H10O5
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
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Reticulol acts as an isocoumarin metabolite that is produced by certain species of Streptomyces. It was first described as a potent inhibitor of cyclic nucleotide PDE (phosphodiesterase). Recent research shows Reticulol exhibits a Topo I (topoisomerase I) inactivation mechanism. It has been reported to cause inhibition of lung metastasis in the B16F10 melanoma model in a dose dependent manner.


Literaturhinweise

1. Mitscher, L.A., et al. 1964. Experientia. 20: 258-259. PMID: 5856305
2. Furutani, Y., et al. 1975. J. Antibiot. 28: 558-560. PMID: 168174
3. Lim, D.S., et al. 2003. Chemotherapy. 49: 146-153. PMID: 12815208
4. Lim, D.S., et al. 2003. Chemotherapy. 49: 257-263. PMID: 14504438

Erscheinung :
Powder
Aggregatzustand :
Solid
Erhaltene Form :
Streptomyces sp.
Löslichkeit :
Soluble in water, methanol, DMSO, ethanol (moderate), and DMF.
LAGERUNG: :
Store at -20° C
Schmelztemperatur :
160.69° C (Predicted)
Sidepunkt :
473.24° C at 760 mmHg (Predicted)
Dichte :
1.43 g/cm3 (Predicted)
Brechungsindex :
n20D 1.62 (Predicted)
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
PubChem CID :
MDL-Nummer :
MFCD11111617
SMILES :
CC1=CC2=CC(=C(C(=C2C(=O)O1)O)OC)O

SDS (MSDS) herunterladen

Analysenzertifikat

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