Date published: 2026-4-24

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Quinocetone (CAS 81810-66-4)

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CAS Number:
81810-66-4
Molecular Weight:
306.32
Molecular Formula:
C18H14N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Quinocetone, a quinoxaline-di-N-oxide derivative, is a chemical known for its applications in non-clinical research contexts, particularly within the realm of agricultural chemistry. The molecule consists of a quinoxaline core structure with ketone functionalities, which are responsible for its interesting chemical and physical properties. Quinocetone has been extensively used in studies focused on understanding the environmental impact and degradation pathways of quinoxaline antibiotics in agricultural settings. Its mechanism of action in these systems involves the formation of complexes with soil and water constituents, influencing its environmental mobility and stability. Research involving quinocetone primarily explores its photodegradation, biodegradation, and its ability to form residues in the environment. These studies are crucial for developing effective strategies for mitigating the impact of similar compounds on ecosystems. Additionally, quinocetone serves as a model compound in analytical chemistry for developing and refining detection methods for quinoxaline derivatives in complex matrices. This research is vital in improving food safety protocols and environmental monitoring, ensuring that the residues of such compounds are tracked and managed effectively, without direct implications in therapeutic or pharmaceutical contexts.


Quinocetone (CAS 81810-66-4) References

  1. Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells.  |  Chen, Q., et al. 2009. Food Chem Toxicol. 47: 328-34. PMID: 19061932
  2. Investigation of quinocetone-induced genotoxicity in HepG2 cells using the comet assay, cytokinesis-block micronucleus test and RAPD analysis.  |  Jin, X., et al. 2009. Toxicol In Vitro. 23: 1209-14. PMID: 19665546
  3. Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders.  |  Yang, W., et al. 2013. J Sci Food Agric. 93: 1317-25. PMID: 23027643
  4. The metabolism of carbadox, olaquindox, mequindox, quinocetone and cyadox: an overview.  |  Liu, ZY. and Sun, ZL. 2013. Med Chem. 9: 1017-27. PMID: 23521002
  5. TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells.  |  Zhang, C., et al. 2013. Food Chem Toxicol. 62: 825-38. PMID: 24161692
  6. Identification of oxidative stress and responsive genes of HepG2 cells exposed to quinocetone, and compared with its metabolites.  |  Zhang, K., et al. 2014. Cell Biol Toxicol. 30: 313-29. PMID: 25223261
  7. Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking.  |  Zhou, Y., et al. 2016. Cell Biol Toxicol. 32: 141-52. PMID: 27085326
  8. Genotoxic risk of quinocetone and its possible mechanism in in vitro studies.  |  Wang, X., et al. 2016. Toxicol Res (Camb). 5: 446-460. PMID: 30090359
  9. Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway.  |  Hou, L., et al. 2022. Toxicol Mech Methods. 32: 49-57. PMID: 34348565
  10. Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway.  |  Dai, C., et al. 2022. Antioxidants (Basel). 11: PMID: 36009217

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Quinocetone, 25 mg

sc-491742
25 mg
$150.00

Quinocetone, 100 mg

sc-491742A
100 mg
$550.00