PP2A-Cα/β Antibody (D-3): sc-376824

PP2A-Cα/β Antibody (D-3) is a mouse monoclonal IgG2b antibody that detects PP2A-Cα/β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PP2A-Cα/β is a critical component of the protein phosphatase 2A (PP2A) family, which plays a vital role in cellular signaling by dephosphorylating serine and threonine residues on target proteins, thereby regulating various cellular processes including cell division, apoptosis, and metabolic homeostasis. PP2A structure is particularly important as a trimeric complex composed of a catalytic subunit, a regulatory subunit, and a variable subunit, which together form a highly versatile enzyme capable of interacting with a diverse array of substrates. This structural complexity allows PP2A to modulate multiple signaling pathways, making PP2A a key player in maintaining cellular function and responding to stress signals. PP2A′s ability to form different holoenzyme configurations through regulatory subunits further enhances functional diversity, underscoring significance in both normal physiology and disease states. With broad species reactivity and proven applications, anti-PP2A-Cα/β antibody (D-3) is an invaluable tool for researchers investigating the intricate roles of protein phosphatases in cellular regulation.

The preferred p-PP2A-Cα/β antibody is p-PP2A-Cα/β Antibody (F-8): sc-271903.