PP2A-C alpha / beta Antibody (D-3): sc-376824

PP2A-Cα/β Antibody (D-3) is a mouse monoclonal IgG2b antibody that detects PP2A-Cα/β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PP2A-Cα/β is a critical component of the protein phosphatase 2A (PP2A) family, which plays a vital role in cellular signaling by dephosphorylating serine and threonine residues on target proteins, thereby regulating various cellular processes including cell division, apoptosis, and metabolic homeostasis. PP2A structure is particularly important as a trimeric complex composed of a catalytic subunit, a regulatory subunit, and a variable subunit, which together form a highly versatile enzyme capable of interacting with a diverse array of substrates. This structural complexity allows PP2A to modulate multiple signaling pathways, making PP2A a key player in maintaining cellular function and responding to stress signals. PP2A′s ability to form different holoenzyme configurations through regulatory subunits further enhances functional diversity, underscoring significance in both normal physiology and disease states. With broad species reactivity and proven applications, anti-PP2A-Cα/β antibody (D-3) is an invaluable tool for researchers investigating the intricate roles of protein phosphatases in cellular regulation.

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PP2A-C alpha / beta Antibody (D-3) References:

1. Involvement of PP2A in viral and cellular transformation.  |  Arroyo, JD. and Hahn, WC. 2005. Oncogene. 24: 7746-55. PMID: 16299534
2. Multiple pathways regulated by the tumor suppressor PP2A in transformation.  |  Westermarck, J. and Hahn, WC. 2008. Trends Mol Med. 14: 152-60. PMID: 18329957
3. The role of PP2A A subunits in tumor suppression.  |  Sablina, AA. and Hahn, WC. 2007. Cell Adh Migr. 1: 140-1. PMID: 19262135
4. Pathologic significance of SET/I2PP2A-mediated PP2A and non-PP2A pathways in polycystic ovary syndrome (PCOS).  |  Jiang, SW., et al. 2017. Clin Chim Acta. 464: 155-159. PMID: 27836688
5. cAMP regulation of protein phosphatases PP1 and PP2A in brain.  |  Leslie, SN. and Nairn, AC. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 64-73. PMID: 30401536
6. Phosphatase PP2A is essential for TH17 differentiation.  |  Xu, Q., et al. 2019. Proc Natl Acad Sci U S A. 116: 982-987. PMID: 30593560
7. Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis.  |  Li, J., et al. 2019. Biochem Biophys Res Commun. 513: 28-34. PMID: 30935690
8. Select Stabilization of a Tumor-Suppressive PP2A Heterotrimer.  |  Shah, VM., et al. 2020. Trends Pharmacol Sci. 41: 595-597. PMID: 32624198
9. PP2A and E3 ubiquitin ligase deficiencies: Seminal biological drivers in endometrial cancer.  |  Gonzalez-Bosquet, J., et al. 2021. Gynecol Oncol. 162: 182-189. PMID: 33867147
10. Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061.  |  Vit, G., et al. 2022. EMBO J. 41: e110611. PMID: 35695070

The preferred p-PP2A-Cα/β antibody is p-PP2A-Cα/β Antibody (F-8): sc-271903.