PP2A-C alpha / beta Antibody (7A6): sc-81601
- PP2A-Cα/β Antibody (7A6) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against unmethylated C-terminal amino acids 302-309 of PP2A-C of human origin
- recommended for detection of PP2A-C α and β isoforms of mouse, rat, human, chicken, Drosophila, S. cerevisiae, S. pombe and Arabidopsis thaliana origin by WB, IP and IHC(P); also reactive with additional species, including and rabbit and porcine
- See PP2A-Cα/β (1D6): sc-80665 for PP2A-Cα/β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PP2A-Cα/β Antibody (7A6) for WB and IHC(P) applications. These reagents are now offered in bundles with PP2A-Cα/β Antibody (7A6) (see ordering information below).
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PP2A-Cα/β Antibody (7A6) is a mouse monoclonal IgG1 antibody that detects PP2A-Cα/β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunohistochemistry. PP2A-Cα/β is a critical component of the protein phosphatase 2A (PP2A) complex, which plays a vital role in cellular signaling by dephosphorylating serine and threonine residues on target proteins, thereby regulating various cellular processes including cell division, apoptosis, and metabolic homeostasis. The structure of PP2A consists of a trimeric assembly formed by a catalytic subunit, a regulatory subunit, and a variable subunit, which together dictate enzyme specificity and activity. PP2A-Cα/β can associate with multiple regulatory subunits, allowing for a diverse range of interactions and functional outcomes, which is crucial for maintaining cellular balance and responding to external stimuli. The ability of PP2A to modulate signaling pathways through structural configuration underscores significance in both normal physiology and disease states, making PP2A-Cα/β an essential target for research in cancer and other disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PP2A-C alpha / beta Antibody (7A6) References:
- Structure, regulation, and pharmacological modulation of PP2A phosphatases. | Lambrecht, C., et al. 2013. Methods Mol Biol. 1053: 283-305. PMID: 23860660
- Regulation of PP2A by Sphingolipid Metabolism and Signaling. | Oaks, J. and Ogretmen, B. 2014. Front Oncol. 4: 388. PMID: 25642418
- From the Biology of PP2A to the PADs for Therapy of Hematologic Malignancies. | Ciccone, M., et al. 2015. Front Oncol. 5: 21. PMID: 25763353
- Mastl/PP2A regulate Cdk1 in ooycte maturation. | Adhikari, D., et al. 2015. Oncotarget. 6: 18734-5. PMID: 26299916
- All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase. | Sangodkar, J., et al. 2016. FEBS J. 283: 1004-24. PMID: 26507691
- The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias. | Pippa, R. and Odero, MD. 2020. Cells. 9: PMID: 32110991
- The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation. | Dzulko, M., et al. 2020. Biochim Biophys Acta Rev Cancer. 1874: 188453. PMID: 33068647
- PP2A Phosphatase as an Emerging Viral Host Factor. | Barski, MS., et al. 2021. Front Cell Infect Microbiol. 11: 725615. PMID: 34422684
- Pleiotropy of PP2A Phosphatases in Cancer with a Focus on Glioblastoma IDH Wildtype. | Kashani, E. and Vassella, E. 2022. Cancers (Basel). 14: PMID: 36358647
- CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation. | Qiu, M., et al. 2023. Sci Adv. 9: eadf8698. PMID: 37205756
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2A-Cα/β Antibody (7A6) | sc-81601 | 200 µg/ml | $322.00 | |||
PP2A-Cα/β Antibody (7A6): m-IgG Fc BP-HRP Bundle | sc-539641 | 200 µg Ab; 10 µg BP | $361.00 | |||
PP2A-Cα/β Antibody (7A6): m-IgG1 BP-HRP Bundle | sc-541624 | 200 µg Ab; 20 µg BP | $361.00 |