PLU-1 Antibody (JARIA3D4): sc-81358
- PLU-1 Antibody (JARIA3D4) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against a recombinant protein corresponding to the C-terminal region of PLU-1 of human origin
- recommended for detection of PLU-1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PLU-1 Antibody (JARIA3D4). This work is in progress.
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PLU-1 Antibody (JARIA3D4) is a mouse monoclonal IgG1 antibody that detects PLU-1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). PLU-1 is a large nuclear protein consisting of 1,544 amino acids and is known for its interactions with developmental transcription factors, including brain factor-1 (BF-1) and paired box 9 (PAX9). PLU-1 is a member of the ARID family of DNA-binding proteins and is categorized within the testis-cancer antigen group, highlighting PLU-1′s significance in cancer research. PLU-1 exhibits strong transcriptional repression properties and shows a unique expression pattern, being predominantly found in the testis and transiently expressed in the pregnant mammary gland. Notably, both PLU-1 gene and protein are specifically upregulated in breast cancer, suggesting a potential role in tumorigenesis. PLU-1′s multi-domain structure is crucial for function, as this allows for binding to chromatin, which may be important for regulating meiotic transcription. PLU-1′s ability to interact with other proteins and restricted expression in adult tissues further underscores PLU-1′s relevance in developmental processes and cancer biology, making anti-PLU-1 antibody (JARIA3D4) an essential tool for researchers studying these areas.
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PLU-1 Antibody (JARIA3D4) References:
- A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. | Lu, PJ., et al. 1999. J Biol Chem. 274: 15633-45. PMID: 10336460
- Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer. | Izawa, A., et al. 2002. Anticancer Res. 22: 2965-9. PMID: 12530026
- Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. | Tan, K., et al. 2003. J Biol Chem. 278: 20507-13. PMID: 12657635
- Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. | Madsen, B., et al. 2002. Mech Dev. 119 Suppl 1: S239-46. PMID: 14516692
- PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis. | Madsen, B., et al. 2003. Chromosoma. 112: 124-32. PMID: 14579128
- PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. | Yamane, K., et al. 2007. Mol Cell. 25: 801-12. PMID: 17363312
- Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. | Barrett, A., et al. 2007. Int J Cancer. 121: 265-75. PMID: 17373667
- FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1. | Katoh, H., et al. 2011. Mol Cell. 44: 770-84. PMID: 22152480
- PLU-1/JARID1B overexpression predicts proliferation properties in head and neck squamous cell carcinoma. | Cui, Z., et al. 2015. Oncol Rep. 33: 2454-60. PMID: 25777981
- Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1. | Lu, Y., et al. 2018. Mol Cancer Res. 16: 1458-1469. PMID: 29934325
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PLU-1 Antibody (JARIA3D4) | sc-81358 | 100 µg/ml | $339.00 |