PIPK I γ Antibody (F-11): sc-390020
- PIPK I γ Antibody (F-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 633-661 at the C-terminus of PIPK I γ of mouse origin
- recommended for detection of PIPK I γ of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PIPK I γ Antibody (F-11) for WB applications. These reagents are now offered in bundles with PIPK I γ Antibody (F-11) (see ordering information below).
PIPK I γ Antibody (F-11) is a mouse monoclonal IgG1 antibody that detects PIPK I γ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PIPK I γ plays a crucial role in cellular signaling by synthesizing phosphatidylinositol-4,5-bisphosphate, a key phospholipid that regulates various cellular processes, including cell proliferation, survival, and cytoskeletal organization. PIPK I γ is involved in the regulation of membrane trafficking and the organization of the cytoskeleton, which are essential for maintaining cellular integrity and facilitating communication between cells. PIPK I γ is expressed in multiple tissues, including the lung, brain, and kidneys, and exists in two variants produced by alternative splicing, highlighting functional diversity and significance in different biological contexts. The PIPK family, which includes type I, type II, and type III kinases, is characterized by distinct substrate specificity and subcellular targeting, with the activation loop playing a pivotal role in determining these properties. PIPK I γ′s ability to phosphorylate phosphatidylinositol-4-phosphate at the 5-hydroxyl position underscores its unique enzymatic function within the PIPK family, making anti-PIPK I γ antibody (F-11) an invaluable tool for researchers studying phosphoinositide signaling pathways and their implications in health and disease.
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PIPK I γ Antibody (F-11) References:
- Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting. | Schill, NJ. and Anderson, RA. 2009. Biochem J. 422: 473-82. PMID: 19548880
- Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. | Volpicelli-Daley, LA., et al. 2010. J Biol Chem. 285: 28708-14. PMID: 20622009
- PIPKIγ targets to the centrosome and restrains centriole duplication. | Xu, Q., et al. 2014. J Cell Sci. 127: 1293-305. PMID: 24434581
- Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment. | Stadtmann, A., et al. 2015. J Immunol. 195: 1152-61. PMID: 26101325
- Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis. | Xu, Q., et al. 2016. Nat Commun. 7: 10777. PMID: 26916822
- The Hidden Conundrum of Phosphoinositide Signaling in Cancer. | Thapa, N., et al. 2016. Trends Cancer. 2: 378-390. PMID: 27819060
- SUMOylation is required for PIPK1γ-driven keratinocyte migration and growth. | Ni, W., et al. 2019. FEBS J. 286: 4709-4720. PMID: 31276292
- Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ. | Chen, C., et al. 2021. Sci Adv. 7: PMID: 34162535
- Targeting type Iγ phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer. | Yu, M., et al. 2022. Theranostics. 12: 4386-4398. PMID: 35673560
- Regulation of NRF2 by Phosphoinositides and Small Heat Shock Proteins. | Chen, C., et al. 2024. bioRxiv.. PMID: 37961303
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIPK I γ Antibody (F-11) | sc-390020 | 200 µg/ml | $322.00 | |||
PIPK I γ Antibody (F-11): m-IgG Fc BP-HRP Bundle | sc-540741 | 200 µg Ab; 10 µg BP | $361.00 | |||
PIPK I γ Antibody (F-11): m-IgG1 BP-HRP Bundle | sc-542339 | 200 µg Ab; 20 µg BP | $361.00 | |||
PIPK I γ (F-11) Neutralizing Peptide | sc-390020 P | 100 µg/0.5 ml | $69.00 |