Pendrin Antibody (C-2): sc-518130

Pendrin Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects Pendrin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pendrin is a crucial transmembrane protein encoded by the gene associated with Pendred syndrome, an autosomal recessive disorder that is the most prevalent form of syndromic deafness, characterized by congenital sensorineural hearing loss and goiter. Pendrin is primarily located in the thyroid, inner ear, fetal cochlea, and kidney, where Pendrin plays a vital role in maintaining ion homeostasis. Specifically, Pendrin functions as an apical anion transporter in the intercalated cells of the proximal tubule and cortical collecting ducts, facilitating the exchange of chloride and bicarbonate ions, which is essential for renal bicarbonate secretion and overall electrolyte balance. Proper functioning of Pendrin is critical, as mutations in the gene can lead to significant health issues, including hearing loss and thyroid dysfunction. Notably, Pendrin expression is markedly reduced in thyroid carcinomas, highlighting Pendrin′s potential role as a biomarker in cancer research. With diverse applications and significant biological relevance, anti-Pendrin antibody (C-2) is an invaluable tool for researchers studying the mechanisms underlying Pendred syndrome and related disorders.

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Pendrin Antibody (C-2) References:

1. The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis.  |  Wagner, CA., et al. 2011. Cell Physiol Biochem. 28: 497-504. PMID: 22116363
2. Pendrin as a novel target for diuretic therapy.  |  Amlal, H. and Soleimani, M. 2011. Cell Physiol Biochem. 28: 521-6. PMID: 22116366
3. Pendrin, a novel transcriptional target of the uroguanylin system.  |  Rozenfeld, J., et al. 2013. Cell Physiol Biochem. 32: 221-37. PMID: 24429828
4. Pendrin and anoctamin as mediators of apical iodide efflux in thyroid cells.  |  Silveira, JC. and Kopp, PA. 2015. Curr Opin Endocrinol Diabetes Obes. 22: 374-80. PMID: 26313899
5. The Significance of Hypothiocyanite Production via the Pendrin/DUOX/Peroxidase Pathway in the Pathogenesis of Asthma.  |  Izuhara, K., et al. 2017. Oxid Med Cell Longev. 2017: 1054801. PMID: 29359006
6. Identification of IQGAP1 as a SLC26A4 (Pendrin)-Binding Protein in the Kidney.  |  Xu, J., et al. 2022. Front Mol Biosci. 9: 874186. PMID: 35601831
7. Pendrin regulation is prioritized by anion in high-potassium diets.  |  Tahaei, E., et al. 2023. Am J Physiol Renal Physiol. 324: F256-F266. PMID: 36656986
8. Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger.  |  Liu, Q., et al. 2023. Nat Commun. 14: 3012. PMID: 37230976
9. Mechanism of anion exchange and small-molecule inhibition of pendrin.  |  Wang, L., et al. 2024. Nat Commun. 15: 346. PMID: 38184688
10. Functional Studies of Deafness-Associated Pendrin and Prestin Variants.  |  Takahashi, S., et al. 2024. Int J Mol Sci. 25: PMID: 38474007

The preferred Pendrin antibody is Pendrin Antibody (G-11): sc-518108.