PA28β Antibody (A8): sc-100799
- PA28β Antibody (A8) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant PA28β of human origin
- recommended for detection of PA28β of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PA28β Antibody (A8). This work is in progress.
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PA28β Antibody (A8) is a mouse monoclonal IgG2a antibody that detects PA28β in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PA28β, also known as PSME2 or REG-β, plays a crucial role as an interferon-γ inducible proteasome activator, essential for the presentation of specific major histocompatibility class I antigens. PA28β is composed of two homologous subunits, PA28α and PA28β, which form a hexameric ring structure that binds to the ends of the 20S proteasome, enhancing proteolytic activity. The unique structure of PA28β allows facilitation of antigenic peptide processing, thereby influencing immune responses. PA28β is expressed constitutively in antigen-presenting cells, and PA28β downregulation has been linked to abnormal proteasome activation, which can contribute to the development of conditions such as intimal hyperplasia in various animal models. Anti-PA28β antibody (A8) is an invaluable tool for researchers studying the dynamics of proteasome activity and its implications in immune regulation and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PA28β Antibody (A8) | sc-100799 | 100 µg/ml | $339.00 |