p73 Antibody (5B1288): sc-56190

p73 Antibody (5B1288) is a mouse monoclonal IgG antibody engineered to recognize the full-length p73 protein, including its α, β, γ, and δ isoforms, as well as the dominant negative variants in human, mouse, and rat samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. Targeting the entire structure of the p73 protein, p73 monoclonal antibody (5B1288) binds to epitopes present in the full-length form, ensuring comprehensive detection without cross-reactivity with the closely related p53 protein. The p73 protein, also known as TP73, is a crucial member of the p53 family of transcription factors, characterized by a multi-domain architecture that includes a highly conserved DNA-binding domain, a transactivation domain, and an oligomerization domain. This structural complexity allows p73 to regulate diverse cellular processes such as apoptosis, cell cycle progression, and differentiation, making p73 integral to maintaining cellular homeostasis and preventing tumorigenesis. The ability of p73 to form tetramers through its oligomerization domain is essential for its function in binding DNA and activating target gene expression. Understanding the structural nuances of p73 is vital for elucidating its role in cancer biology, as different isoforms can have opposing effects on cell fate decisions. p73 monoclonal antibody (5B1288) provides researchers with a reliable tool to study the intricate structural and functional dynamics of p73 isoforms, facilitating advancements in cancer research and the development of targeted therapies. By enabling precise detection and analysis of p73 variants, anti-p73 antibody (5B1288) supports the exploration of p73′s multifaceted roles in tumor suppression and its interactions with other cellular proteins, thereby contributing to a deeper understanding of cancer mechanisms and potential therapeutic interventions.

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p73 Antibody (5B1288) References:

1. p73: a multifunctional protein in neurobiology.  |  Killick, R., et al. 2011. Mol Neurobiol. 43: 139-46. PMID: 21380933
2. Alterations of p63 and p73 in human cancers.  |  Inoue, K. and Fry, EA. 2014. Subcell Biochem. 85: 17-40. PMID: 25201187
3. p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms.  |  Vikhreva, P., et al. 2018. J Mol Biol. 430: 1829-1838. PMID: 29733853
4. Tissue-specific roles of p73 in development and homeostasis.  |  Nemajerova, A. and Moll, UM. 2019. J Cell Sci. 132: PMID: 31582429
5. Transcription factor p73 regulates Th1 differentiation.  |  Ren, M., et al. 2020. Nat Commun. 11: 1475. PMID: 32193462
6. P73 C-terminus is dispensable for multiciliogenesis.  |  Buckley, N., et al. 2020. Cell Cycle. 19: 1833-1845. PMID: 32584647
7. p73: From the p53 shadow to a major pharmacological target in anticancer therapy.  |  Ramos, H., et al. 2020. Pharmacol Res. 162: 105245. PMID: 33069756
8. Mechanisms of Functional Pleiotropy of p73 in Cancer and Beyond.  |  Logotheti, S., et al. 2021. Front Cell Dev Biol. 9: 737735. PMID: 34650986
9. Dual Role of p73 in Cancer Microenvironment and DNA Damage Response.  |  Rozenberg, JM., et al. 2021. Cells. 10: PMID: 34944027
10. Structural diversity of p63 and p73 isoforms.  |  Osterburg, C. and Dötsch, V. 2022. Cell Death Differ. 29: 921-937. PMID: 35314772

The preferred p73 antibody is p73 Antibody (E-4): sc-17823.