Date published: 2026-5-21

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p-Iodoclonidine hydrochloride (CAS 108294-53-7)

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Alternate Names:
2-[(2,6-Dichloro-4-iodophenyl)imino]imidazoline hydrochloride
Application:
p-Iodoclonidine hydrochloride is A high affinity α2 adrenergic receptor agonist
CAS Number:
108294-53-7
Molecular Weight:
392.45
Molecular Formula:
C9H8Cl2IN3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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A high affinity α2 adrenergic receptor agonist.


p-Iodoclonidine hydrochloride (CAS 108294-53-7) References

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  2. Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.  |  Cockcroft, V., et al. 2000. J Neurochem. 74: 1705-10. PMID: 10737629
  3. Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).  |  Brink, CB., et al. 2000. J Pharmacol Exp Ther. 294: 539-47. PMID: 10900230
  4. The influence of fulvic and ulmic acids from peat, on the spontaneous contractile activity of smooth muscles.  |  Beer, AM., et al. 2000. Phytomedicine. 7: 407-15. PMID: 11081992
  5. Stimulation of sodium-dependent inorganic phosphate transport by activation of Gi/o-protein-coupled receptors by epinephrine in MC3T3-E1 osteoblast-like cells.  |  Suzuki, A., et al. 2001. Bone. 28: 589-94. PMID: 11425646
  6. Isolation of biologically active fractions from the water soluble components of fulvic and ulmic acids from peat.  |  Beer, AM., et al. 2002. Phytomedicine. 9: 659-66. PMID: 12487332
  7. Effect of Thymol on the spontaneous contractile activity of the smooth muscles.  |  Beer, AM., et al. 2007. Phytomedicine. 14: 65-9. PMID: 17187972
  8. p-[125I]iodoclonidine, a novel radiolabeled agonist for studying central alpha 2-adrenergic receptors.  |  Baron, BM. and Siegel, BW. 1990. Mol Pharmacol. 38: 348-56. PMID: 1976227
  9. Investigations into the specific effects of rosemary oil at the receptor level.  |  Sagorchev, P., et al. 2010. Phytomedicine. 17: 693-7. PMID: 20034774
  10. Retigabine diminishes the effects of acetylcholine, adrenaline and adrenergic agonists on the spontaneous activity of guinea pig smooth muscle strips in vitro.  |  Apostolova, E., et al. 2017. Auton Neurosci. 203: 51-57. PMID: 28041987
  11. Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors.  |  Piletz, JE., et al. 1995. J Pharmacol Exp Ther. 272: 581-7. PMID: 7853171
  12. Binding and functional characterization of alpha-2 adrenergic receptor subtypes on pig vascular endothelium.  |  Bockman, CS., et al. 1993. J Pharmacol Exp Ther. 267: 1126-33. PMID: 7903385
  13. Chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction.  |  Reid, K., et al. 1997. Pharmacol Biochem Behav. 57: 63-71. PMID: 9164555
  14. Evidence for the existence of imidazoline-specific binding sites in synaptosomal plasma membranes of the bovine brainstem.  |  Heemskerk, FM., et al. 1998. J Neurochem. 71: 2193-202. PMID: 9798947

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

p-Iodoclonidine hydrochloride, 25 mg

sc-257955
25 mg
$45.00