CKR-5 für die funktionelle Analyse zellulärer Antworten auf C-C Chemokine Receptor
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C-C or b chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potent chemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include, CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7 and the Duffy blood group antigen (2,3,7,8). Each of these receptors are G-protein coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation. However, this receptor family has also been shown to facilitate viral infection. Termed a "coreceptor", CKR-5, along with CD4, has been shown to be a major receptor for HIV. CKR-5 tends to associate with macrophage-tropic viruses, such as macrophage tropic HIV-1, while CKR-2B and CKR-3 bind a minority of viruses. Agonist binding to the CKR-5 induces the phosphorylation of four distinct serine residues that are located in the CKR-5 carboxy terminus. This terminus is involved in the coupling to G-proteins and also contains a cysteine site along with the phosphorylation sites, and all are involved in receptor desensitization.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
What is the recommended starting dilution for Western blot for p-CKR-5 (V14/2): sc-32303 monoclonal antibody?
Gefragt von: Germaine
Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link:
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