NOSIP Antibody (B-3): sc-137118

NOSIP Antibody (B-3) is a mouse monoclonal IgG2b antibody that detects NOSIP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NOSIP, or endothelial nitric oxide synthase interacting protein, plays a crucial role in modulating the activity of endothelial nitric oxide synthase (eNOS), an essential enzyme responsible for the generation of nitric oxide (NO) in the vasculature. The regulation of eNOS is vital for maintaining vascular tone and blood flow, as well as for various physiological processes including angiogenesis and neurotransmission. NOSIP influences eNOS activity by facilitating its translocation from the plasma membrane to intracellular compartments, thereby inhibiting NO synthesis. This modulation is particularly important in the context of airway and vascular diameter control, as well as in the synthesis of NO in ciliated epithelial cells, which is critical for mucociliary clearance and bronchial function. Highly expressed in endothelial cells and vascularized tissues, NOSIP′s interaction with eNOS and other regulatory proteins underscores its significance in cardiovascular health and disease. Anti-NOSIP antibody (B-3) is an invaluable tool for researchers investigating the intricate mechanisms of nitric oxide signaling and its implications in various biological processes.

The preferred NOSIP antibody is NOSIP Antibody (C-2): sc-365363.