Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
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MYL1 Antibody (L-13) is a high quality monoclonal MYL1 antibody (also designated MYL1 antibody) suitable for the detection of the MYL1 protein of human origin. MYL1 Antibody (L-13) is available as the non-conjugated anti-MYL1 antibody. Myosin, the major component of thick muscle filaments, is a long asymmetric molecule containing a globular head and a long tail. Activation of smooth and cardiac/ventricular muscle primarily involves pathways which increase calcium and myosin phosphorylation, resulting in contraction. Myosin in vertebrate striated muscle is composed of two heavy chains and four light chains. There are two distinct types of light chains: the phosphorylatable, regulatory or MLC2 type; and the nonphosphorylatable, alkali or MLC1 and MLC3 types. Myosin light chain phosphatase acts to regulate muscle contraction by de-phosphorylating activated myosin light chain. The role of myosin alkali light chains in vertebrate skeletal muscle is poorly understood, although alkali light chains in smooth muscle may be involved with the active site of myosin. Several isoforms of myosin alkali light chains have been identified, encoded by a family of myosin light chain genes. Each is associated with different muscle types. MYL1 (Myosin light chain 3, skeletal muscle isoform), also known as MLC1F or MLC3F, is a hexameric ATPase cellular motor protein that is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. MYL1 is expressed in fast skeletal muscle and two isoforms exist due to alternative splicing.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-100342: MYL1 (L-13) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Gefragt von: jerojero
Thank you for your question. Yes, sc-100342: MYL1 (L-13) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
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