Molecular structure of MTEP, CAS Number: 329205-68-7
MTEP (CAS 329205-68-7)
Application:
MTEP is a selective, potent and non-competitive antagonist of mGluR5 with anxiolytic activity
CAS Number:
329205-68-7
Molecular Weight:
200.3
Molecular Formula:
C11H8N2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MTEP is a selective, non-competitive antagonist at the metabotropic glutamate receptor subtype 5 (mGluR5). It functions by binding to the receptor and inhibiting its activity, thereby modulating glutamatergic neurotransmission. MTEP′s mechanism of action involves blocking the effects of glutamate at the mGluR5 receptor, which plays a role in synaptic plasticity and neuronal signaling. Its mechanism of action at the molecular level allows for the investigation of the specific functions and signaling pathways associated with mGluR5, contributing to a deeper understanding of neurobiological processes.
MTEP (CAS 329205-68-7) References
- [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. | Anderson, JJ., et al. 2002. J Pharmacol Exp Ther. 303: 1044-51. PMID: 12438526
- Reduced stress-induced hyperthermia in mGluR5 knockout mice. | Brodkin, J., et al. 2002. Eur J Neurosci. 16: 2241-4. PMID: 12473093
- [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. | Cosford, ND., et al. 2003. Bioorg Med Chem Lett. 13: 351-4. PMID: 12565928
- Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. | Klodzinska, A., et al. 2004. Neuropharmacology. 47: 342-50. PMID: 15275823
- Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. | Lea, PM., et al. 2005. Br J Pharmacol. 145: 527-34. PMID: 15821750
- Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. | Lea, PM. and Faden, AI. 2006. CNS Drug Rev. 12: 149-66. PMID: 16958988
- Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer. | Martin-Fardon, R., et al. 2009. J Pharmacol Exp Ther. 329: 1084-90. PMID: 19258516
- Physical and crystallographic characterisation of the mGlu5 antagonist MTEP and its monohydrochloride. | McIldowie, MJ., et al. 2010. J Pharm Sci. 99: 234-45. PMID: 19499574
- Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus. | Domin, H., et al. 2010. Pharmacol Rep. 62: 1051-61. PMID: 21273662
- mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties. | Swedberg, MD., et al. 2014. J Pharmacol Exp Ther. 349: 155-64. PMID: 24472725
- MTEP impedes the neuronal polarization and the activity of the Akt-NF-κB pathway in rat hippocampal neurons. | Zhang, X., et al. 2017. J Neurosci Res. 95: 1730-1744. PMID: 28019025
- Curos™ Disinfection Caps for the Prevention of Infection When Using Needleless Connectors: A NICE Medical Technologies Guidance. | O'Connell, S., et al. 2021. Appl Health Econ Health Policy. 19: 145-153. PMID: 32754850
- Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2. | Stachowicz, K., et al. 2021. Neurosci Lett. 741: 135435. PMID: 33171212
- MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy. | Dyomina, AV., et al. 2022. Int J Mol Sci. 23: PMID: 35008924
Inhibitor of:
mGluR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTEP, 5 mg | sc-205956 | 5 mg | $88.00 | |||
MTEP, 25 mg | sc-205956A | 25 mg | $348.00 |