MCP-1 Antibody (5D3-F7): sc-32786

MCP-1 Antibody (5D3-F7) is a mouse monoclonal IgG1 antibody that detects MCP-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). MCP-1, also known as CCL2, plays a crucial role in the immune response by mediating the recruitment of monocytes to sites of inflammation, which is vital for effective immune surveillance and tissue repair. This chemokine is primarily secreted by activated T lymphocytes and various other cell types in response to pro-inflammatory cytokines like interleukin-1, tumor necrosis factor-alpha, and interferon-gamma. The ability of MCP-1 to attract monocytes is particularly important during infection and inflammatory processes, as MCP-1 facilitates the accumulation of immune cells at the site of injury or infection, thereby enhancing the body′s ability to combat pathogens. Additionally, MCP-1 interacts with two distinct receptors, CCR2 and CCR4, which are essential for mediating biological effects, including monocyte activation and migration. Anti-MCP-1 antibody (5D3-F7) is an invaluable tool for researchers studying the dynamics of immune responses and the underlying mechanisms of various inflammatory diseases.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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MCP-1 Antibody (5D3-F7) References:

1. Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes.  |  Panee, J. 2012. Cytokine. 60: 1-12. PMID: 22766373
2. MCP-1 Levels are Associated with Cardiac Remodeling but not with Resistant Hypertension.  |  Ritter, AMV., et al. 2017. Arq Bras Cardiol. 108: 331-338. PMID: 28380135
3. MCP-1 mediates ischemia-reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR.  |  Zhang, W., et al. 2020. Am J Physiol Heart Circ Physiol. 318: H59-H71. PMID: 31774703
4. Urinary EGF and MCP-1 and risk of CKD after cardiac surgery.  |  Menez, S., et al. 2021. JCI Insight. 6: PMID: 33974569
5. MCP-1 Signaling Disrupts Social Behavior by Modulating Brain Volumetric Changes and Microglia Morphology.  |  Maldonado-Ruiz, R., et al. 2022. Mol Neurobiol. 59: 932-949. PMID: 34797523
6. Phagocyte Chemoattraction Is Induced through the Mcp-1-Ccr2 Axis during Efferocytosis.  |  Lee, SA., et al. 2021. Cells. 10: PMID: 34831339
7. RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.  |  Huang, S., et al. 2022. J Stroke Cerebrovasc Dis. 31: 106213. PMID: 34837868
8. Expression levels of MCP-1, HGF, and IGF-1 in endometriotic patients compared with non-endometriotic controls.  |  Heidari, S., et al. 2021. BMC Womens Health. 21: 422. PMID: 34930225
9. Effect of Flavonoids on MCP-1 Expression in Human Coronary Artery Endothelial Cells and Impact on MCP-1-Dependent Migration of Human Monocytes.  |  Brüser, L., et al. 2023. Int J Mol Sci. 24: PMID: 38003237
10. Targeting cardiac resident CCR2+ macrophage-secreted MCP-1 to attenuate inflammation after myocardial infarction.  |  Wen, J., et al. 2024. Acta Biomater.. PMID: 39182804

The preferred MCP-1 antibody is MCP-1 Antibody (5J): sc-32771.