Ly-6C Antibody (ER-MP20): sc-52650
- Ly-6C Antibody (ER-MP20) is a rat monoclonal IgG2a, cited in 7 publications, provided at 200 µg/ml
- raised against a macrophage cell line of mouse origin
- recommended for detection of Ly-6C of mouse origin by IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ly-6C Antibody (ER-MP20). This work is in progress.
Ly-6C Antibody (ER-MP20) is a rat monoclonal IgG2a antibody that detects Ly-6C in mouse samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Ly-6C antibody (ER-MP20) recognizes a 131 amino acid protein that belongs to the Ly-6 family of glycosyl-phosphatidylinositol (GPI)-anchored proteins, characterized by a distinctive cysteine-rich domain containing O-linked carbohydrates. Ly-6C plays a crucial role in immune response, particularly in CD8 T cell activation and regulation, which are essential for targeting and eliminating infected or malignant cells. Ly-6C (ER-MP20) monoclonal antibody detects proteins predominantly expressed on murine peripheral CD8 T cells, involved in endothelial adhesion, cytotoxic T lymphocyte (CTL) activity, and production of key cytokines like interleukin-2 and interferon-gamma. Ly-6C may function as a signaling molecule enhancing lymphocyte function-associated antigen 1 (LFA-1) activation, facilitating CD8 T cell migration and homing to inflammation or infection sites. Unique expression patterns of Ly-6C during hematopoiesis and specific presence on leukocyte subpopulations highlight its importance in normal immune function and potential therapeutic applications.
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Ly-6C Antibody (ER-MP20) References:
- Ly-6 superfamily members Ly-6A/E, Ly-6C, and Ly-6I recognize two potential ligands expressed by B lymphocytes. | Pflugh, DL., et al. 2002. J Immunol. 169: 5130-6. PMID: 12391229
- Absence of cross-reactivity between murine Ly-6C and Ly-6G. | Nagendra, S. and Schlueter, AJ. 2004. Cytometry A. 58: 195-200. PMID: 15057973
- Identification of splenic reservoir monocytes and their deployment to inflammatory sites. | Swirski, FK., et al. 2009. Science. 325: 612-6. PMID: 19644120
- Plasticity of Ly-6C(hi) myeloid cells in T cell regulation. | Zhu, B., et al. 2011. J Immunol. 187: 2418-32. PMID: 21824867
- Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. | Robbins, CS., et al. 2012. Circulation. 125: 364-74. PMID: 22144566
- Expansion of CD11b+Ly-6C+ myeloid-derived suppressor cells (MDSCs) driven by galectin-9 attenuates CVB3-induced myocarditis. | Zhang, Y., et al. 2017. Mol Immunol. 83: 62-71. PMID: 28110209
- Exacerbation of Japanese Encephalitis by CD11chi Dendritic Cell Ablation Is Associated with an Imbalance in Regulatory Foxp3+ and IL-17+CD4+ Th17 Cells and in Ly-6Chi and Ly-6Clo Monocytes. | Choi, JY., et al. 2017. Immune Netw. 17: 192-200. PMID: 28680381
- Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G. | Morimoto, J., et al. 2018. J Immunol. 201: 3244-3257. PMID: 30389776
- CD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation. | Izumi, G., et al. 2021. Nat Commun. 12: 5029. PMID: 34413303
- Ly-6C is expressed in brain vessels endothelial cells but not in microglia of the mouse. | Alliot, F., et al. 1998. Neurosci Lett. 251: 37-40. PMID: 9714459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ly-6C Antibody (ER-MP20) | sc-52650 | 200 µg/ml | $322.00 | |||
Ly-6C Antibody (ER-MP20) FITC | sc-52650 FITC | 200 µg/ml | $336.00 | |||
Ly-6C Antibody (ER-MP20) PE | sc-52650 PE | 200 µg/ml | $349.00 |