LTB4R2 Antibody (B-12): sc-518262
- LTB4R2 Antibody (B-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 341-369 of LTB4R2 of human origin
- recommended for detection of LTB4R2 of human origin by WB, IP, IF and ELISA
- Anti-LTB4R2 Antibody (B-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for LTB4R2 Antibody (B-12) for WB applications. This reagent is now offered in a bundle with LTB4R2 Antibody (B-12) (see ordering information below).
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SEE ALSO...
LTB4R2 Antibody (B-12) is an IgG1 κ mouse monoclonal LTB4R2 antibody (also designated LTB4R2 antibody) that detects LTB4R2 of human origin by WB, IP, IF and ELISA. LTB4R2 Antibody (B-12) is available as the non-conjugated anti-LTB4R2 antibody form, as well as multiple conjugated forms of anti-LTB4R2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The P2Y receptor family consists of G-protein coupled receptors, which mediate the effects of extracellular nucleotides, primarily through the activation of phospholipase C. The P2Y receptors are important in the activation of leukocytes and platelets in response to inflammation or vascular damage. Leukotriene B4 receptor 1 (LTB4-R1), also designated P2Y purinoceptor 7, is a receptor for extracellular ATP, UTP and ADP. Through modulation of L-type calcium currents, LTB4-R1 is involved in the regulation of cardiac muscle contraction. It is also a receptor for leukotriene B4 (LTB4), a potent chemoattractant involved in inflammation and immumne response. Leukotriene B4 receptor 2 (LTB4R2) is a ubiquitously expressed 358-amino acid receptor for LTB4. It is an integral membrane protein acting as a receptor for leukotrienes, is widely expressed and mediates chemotaxis of macrophages and granulocytes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LTB4R2 Antibody (B-12) References:
- Molecular cloning and characterization of another leukotriene B4 receptor. | Kamohara, M., et al. 2000. J Biol Chem. 275: 27000-4. PMID: 10889186
- Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. | Tryselius, Y., et al. 2000. Biochem Biophys Res Commun. 274: 377-82. PMID: 10913346
- Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14. | Nilsson, NE., et al. 2000. Biochem Biophys Res Commun. 274: 383-8. PMID: 10913347
- Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. | Kato, K., et al. 2000. J Exp Med. 192: 413-20. PMID: 10934229
- A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. | Yokomizo, T., et al. 2000. J Exp Med. 192: 421-32. PMID: 10934230
- A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. | Wang, S., et al. 2000. J Biol Chem. 275: 40686-94. PMID: 11006272
- Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. | Yokomizo, T., et al. 2001. J Biol Chem. 276: 12454-9. PMID: 11278893
- Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. | Ishii, Y., et al. 2016. FASEB J. 30: 933-47. PMID: 26527063
- BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer. | Park, J., et al. 2018. BMB Rep. 51: 373-377. PMID: 29898809
- Leukotriene B4 receptor 2 correlates with prognosis and immune infiltration in clear cell renal cell carcinoma. | Yuan, X., et al. 2022. Invest New Drugs. 40: 232-244. PMID: 34633577
- Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation. | Jang, JH., et al. 2021. Exp Mol Med. 53: 1559-1568. PMID: 34635780
- Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation. | Ermis, E., et al. 2024. J Biol Chem. 300: 105561. PMID: 38097183
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTB4R2 Antibody (B-12) | sc-518262 | 200 µg/ml | $322.00 | |||
LTB4R2 Antibody (B-12): m-IgG1 BP-HRP Bundle | sc-551764 | 200 µg Ab; 20 µg BP | $361.00 | |||
LTB4R2 Antibody (B-12) AC | sc-518262 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LTB4R2 Antibody (B-12) HRP | sc-518262 HRP | 200 µg/ml | $322.00 | |||
LTB4R2 Antibody (B-12) FITC | sc-518262 FITC | 200 µg/ml | $336.00 | |||
LTB4R2 Antibody (B-12) PE | sc-518262 PE | 200 µg/ml | $349.00 | |||
LTB4R2 Antibody (B-12) Alexa Fluor® 488 | sc-518262 AF488 | 200 µg/ml | $364.00 | |||
LTB4R2 Antibody (B-12) Alexa Fluor® 546 | sc-518262 AF546 | 200 µg/ml | $364.00 | |||
LTB4R2 Antibody (B-12) Alexa Fluor® 594 | sc-518262 AF594 | 200 µg/ml | $364.00 | |||
LTB4R2 Antibody (B-12) Alexa Fluor® 647 | sc-518262 AF647 | 200 µg/ml | $364.00 | |||
LTB4R2 Antibody (B-12) Alexa Fluor® 680 | sc-518262 AF680 | 200 µg/ml | $364.00 | |||
LTB4R2 Antibody (B-12) Alexa Fluor® 790 | sc-518262 AF790 | 200 µg/ml | $364.00 |