LIFR Antibody (H-7): sc-515492

LIFR Antibody (H-7) is a mouse monoclonal IgG2a antibody that detects LIFR in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LIFR, or leukemia inhibitory factor receptor, plays a crucial role in mediating the effects of leukemia inhibitory factor, which is essential for various cellular processes, including cell survival, differentiation, and proliferation. LIFR protein is primarily located on the cell surface, where LIFR forms a receptor complex with gp130, facilitating the transduction of signals that influence cell fate decisions. This localization allows LIFR to respond to extracellular signals and activate intracellular pathways that can lead to significant biological outcomes, such as the regulation of immune responses and the maintenance of stem cell pluripotency. Additionally, LIFR is known to interact with other cytokine receptors, enhancing functional versatility and underscoring importance in various physiological and pathological contexts. Anti-LIFR antibody (H-7) is an invaluable tool for researchers studying these complex signaling pathways and their implications in health and disease.

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LIFR Antibody (H-7) References:

1. Leukemia inhibitory factor receptor α-chain: a potential method for acute promyeloid leukemia therapy.  |  Sun, Q., et al. 2012. Med Hypotheses. 79: 864-6. PMID: 23046857
2. Leukemia inhibitory factor receptor is a novel immunomarker in distinction of well-differentiated HCC from dysplastic nodules.  |  Luo, Q., et al. 2015. Oncotarget. 6: 6989-99. PMID: 25749520
3. Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer.  |  Zeng, H., et al. 2016. Cancer Cell. 30: 459-473. PMID: 27622335
4. Decreased Endometrial Expression of Leukemia Inhibitory Factor Receptor Disrupts the STAT3 Signaling in Adenomyosis During the Implantation Window.  |  Yen, CF., et al. 2017. Reprod Sci. 24: 1176-1186. PMID: 27903796
5. Leukemia Inhibitory Factor-Receptor is Dispensable for Prenatal Testis Development but is Required in Sertoli cells for Normal Spermatogenesis in Mice.  |  Curley, M., et al. 2018. Sci Rep. 8: 11532. PMID: 30068994
6. Leukemia Inhibitory Factor Receptor Is Involved in Apoptosis in Rat Astrocytes Exposed to Oxygen-Glucose Deprivation.  |  Huo, L., et al. 2019. Biomed Res Int. 2019: 1613820. PMID: 30937308
7. Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells.  |  Wang, T., et al. 2019. Mol Med Rep. 19: 4719-4726. PMID: 31059010
8. Interplay of 'leukemia inhibitory factor receptor gene' (rs3099124) polymorphism, leukemia inhibitory factor and ovarian steroids with unexplained infertility.  |  Ali, R., et al. 2023. Nucleosides Nucleotides Nucleic Acids. 42: 718-730. PMID: 36924393
9. PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness.  |  Streitfeld, WS., et al. 2023. Cancer Biol Ther. 24: 2271638. PMID: 37927213
10. Leukemia inhibitory factor receptor inhibition by EC359 reduces atherosclerotic stenosis grade in Ldlr-/- mice.  |  Hemme, E., et al. 2024. Eur J Pharmacol. 985: 177121. PMID: 39528103

The preferred LIFR antibody is LIFR Antibody (A-10): sc-515337.