LIFR Antibody (AN-E1): sc-9995
- LIFR Antibody (AN-E1) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against full length soluble LIF receptor of human origin
- recommended for detection of LIFR of human origin by IP, ELISA and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LIFR Antibody (AN-E1). These reagents are now offered in bundles with LIFR Antibody (AN-E1) (see ordering information below).
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LIFR Antibody (AN-E1) is a mouse monoclonal IgG1 antibody that detects LIFR in human samples through applications such as immunoprecipitation (IP), enzyme-linked immunosorbent assay (ELISA), and flow cytometry (FCM). LIFR, or leukemia inhibitory factor receptor, plays a crucial role in mediating the effects of leukemia inhibitory factor, which is essential for various cellular processes, including cell survival, differentiation, and proliferation. LIFR protein is primarily located on the cell surface, where LIFR forms a complex with gp130, a common signal transducer for several cytokines. This interaction is vital for initiating intracellular signaling pathways that regulate immune responses and hematopoiesis. Importantly, LIFR presence on the cell surface allows for the modulation of these pathways in response to environmental cues, making LIFR a key player in maintaining homeostasis and responding to stress. LIFR monoclonal antibody (AN-E1) is an invaluable tool for researchers studying the intricate signaling mechanisms involved in cell communication and the pathophysiology of various diseases, including cancer and autoimmune disorders.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LIFR Antibody (AN-E1) References:
- The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1. | Qadi, AA., et al. 2016. J Cell Biochem. 117: 49-58. PMID: 26060100
- The Role of Leukemia Inhibitory Factor Receptor Signaling in Skeletal Muscle Growth, Injury and Disease. | Hunt, LC. and White, J. 2016. Adv Exp Med Biol. 900: 45-59. PMID: 27003396
- Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations. | Kosfeld, A., et al. 2017. Hum Mol Genet. 26: 1716-1731. PMID: 28334964
- The role of the leukemia inhibitory factor receptor in neuroprotective signaling. | Davis, SM. and Pennypacker, KR. 2018. Pharmacol Ther. 183: 50-57. PMID: 28827150
- A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. | Yao, F., et al. 2021. Nat Commun. 12: 7333. PMID: 34921145
- Leukemia inhibitory factor-receptor signalling negatively regulates gonadotrophin-stimulated testosterone production in mouse Leydig Cells. | Curley, M., et al. 2022. Mol Cell Endocrinol. 544: 111556. PMID: 35031431
- Targeting LIF/LIFR signaling in cancer. | Viswanadhapalli, S., et al. 2022. Genes Dis. 9: 973-980. PMID: 35685476
- Role and mechanism of leukemia inhibitory factor receptor in cervical cancer invasion and metastasis. | Hu, H., et al. 2023. J Int Med Res. 51: 3000605231182557. PMID: 37357760
- LIFR regulates cholesterol-driven bidirectional hepatocyte-neutrophil cross-talk to promote liver regeneration. | Deng, Y., et al. 2024. Nat Metab. 6: 1756-1774. PMID: 39147934
- Roles of leukemia inhibitory factor receptor in cancer. | Ma, W., et al. 2025. Int J Cancer. 156: 262-273. PMID: 39279155
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LIFR Antibody (AN-E1) | sc-9995 | 200 µg/ml | $322.00 | |||
LIFR Antibody (AN-E1): m-IgG Fc BP-HRP Bundle | sc-536570 | 200 µg Ab; 10 µg BP | $361.00 | |||
LIFR Antibody (AN-E1): m-IgGκ BP-HRP Bundle | sc-533721 | 200 µg Ab; 40 µg BP | $361.00 | |||
LIFR Antibody (AN-E1): m-IgG1 BP-HRP Bundle | sc-544683 | 200 µg Ab; 20 µg BP | $361.00 | |||
LIFR Antibody (AN-E1) FITC | sc-9995 FITC | 200 µg/ml | $336.00 | |||
LIFR Antibody (AN-E1) PE | sc-9995 PE | 200 µg/ml | $349.00 |