KV2.2 Antibody (E-7): sc-376275
- KV2.2 Antibody (E-7) is a mouse monoclonal IgG1 κ KV2.2 antibody provided at 200 µg/ml
- raised against amino acids 717-759 mapping near the C-terminus of KV2.2 of human origin
- KV2.2 Antibody (E-7) is recommended for detection of KV2.2 of human origin by WB, IP, IF and ELISA
- Anti-KV2.2 Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KV2.2 Antibody (E-7) for WB applications. These reagents are now offered in bundles with KV2.2 Antibody (E-7) (see ordering information below).
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KV2.2 Antibody (E-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects KV2.2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KV2.2 Antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KV2.2 plays a crucial role in regulating voltage-gated potassium channels, which are essential for maintaining electrical excitability of neurons and muscle cells. These channels are responsible for repolarizing membrane potential after action potentials, thereby influencing frequency and timing of neuronal firing. KV gene family, which includes over 30 different proteins, encodes subunits that form these channels, each exhibiting unique gating and permeation characteristics. KV2.2 is a multi-pass membrane protein that contributes to voltage-dependent potassium permeability of excitable membranes and possesses a cytoplasmic tail critical for targeting channels to specific subcellular compartments and modulating activity. Understanding KV2.2 function and regulation is vital for elucidating its role in various physiological processes and potential pathophysiological conditions, making anti-KV2.2 antibody (E-7) an invaluable tool for researchers studying ion channel dynamics and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KV2.2 Antibody (E-7) References:
- Electrically silent potassium channel subunits from human lens epithelium. | Shepard, AR. and Rae, JL. 1999. Am J Physiol. 277: C412-24. PMID: 10484328
- Carboxyl tail region of the Kv2.2 subunit mediates novel developmental regulation of channel density. | Blaine, JT., et al. 2004. J Neurophysiol. 92: 3446-54. PMID: 15306626
- Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits. | Kerschensteiner, D., et al. 2005. Proc Natl Acad Sci U S A. 102: 6160-5. PMID: 15827117
- Kv channels contribute to nitric oxide- and atrial natriuretic peptide-induced relaxation of a rat conduit artery. | Tanaka, Y., et al. 2006. J Pharmacol Exp Ther. 317: 341-54. PMID: 16394199
- The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing. | Deal, KK., et al. 1994. J Neurosci. 14: 1666-76. PMID: 8126562
- Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain. | Veh, RW., et al. 1995. Eur J Neurosci. 7: 2189-205. PMID: 8563969
- Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. | Schmalz, F., et al. 1998. Am J Physiol. 274: G901-11. PMID: 9612272
- Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. | Leicher, T., et al. 1998. J Biol Chem. 273: 35095-101. PMID: 9857044
- Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells. | Lan, M., et al. 2005. Cancer Biol Ther. 4: 1342-7. PMID: 16258262
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KV2.2 Antibody (E-7) | sc-376275 | 200 µg/ml | $322.00 | |||
KV2.2 Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-529847 | 200 µg Ab; 10 µg BP | $361.00 | |||
KV2.2 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-522906 | 200 µg Ab, 40 µg BP | $361.00 | |||
KV2.2 Antibody (E-7) AC | sc-376275 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KV2.2 Antibody (E-7) HRP | sc-376275 HRP | 200 µg/ml | $322.00 | |||
KV2.2 Antibody (E-7) FITC | sc-376275 FITC | 200 µg/ml | $336.00 | |||
KV2.2 Antibody (E-7) PE | sc-376275 PE | 200 µg/ml | $349.00 | |||
KV2.2 Antibody (E-7) Alexa Fluor® 488 | sc-376275 AF488 | 200 µg/ml | $364.00 | |||
KV2.2 Antibody (E-7) Alexa Fluor® 546 | sc-376275 AF546 | 200 µg/ml | $364.00 | |||
KV2.2 Antibody (E-7) Alexa Fluor® 594 | sc-376275 AF594 | 200 µg/ml | $364.00 | |||
KV2.2 Antibody (E-7) Alexa Fluor® 647 | sc-376275 AF647 | 200 µg/ml | $364.00 | |||
KV2.2 Antibody (E-7) Alexa Fluor® 680 | sc-376275 AF680 | 200 µg/ml | $364.00 | |||
KV2.2 Antibody (E-7) Alexa Fluor® 790 | sc-376275 AF790 | 200 µg/ml | $364.00 |