Ksr-1 Antibody (MINT/1/4): sc-56923
- Ksr-1 Antibody (MINT/1/4) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against recombinant Ksr-1-GST fusion protein-GST fusion protein of human origin
- recommended for detection of Ksr-1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ksr-1 Antibody (MINT/1/4). This work is in progress.
Ksr-1 Antibody (MINT/1/4) is a rat monoclonal IgG2a antibody that detects Ksr-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ksr-1, or kinase suppressor of Ras, plays a crucial role in the Ras signaling pathway, which is essential for various cellular processes, including growth, differentiation, and survival. Ksr-1 is primarily located in the cytoplasm and acts as a scaffold that facilitates the interaction between Ras and Raf-1, thereby promoting the activation of downstream signaling cascades. Proper functioning of Ksr-1 is vital, as dysregulation of this pathway can lead to various diseases, including cancer. Ksr-1′s ability to modulate Ras signaling highlights its importance in maintaining cellular homeostasis and underscores the relevance of studying Ksr-1 in the context of signal transduction research. Anti-Ksr-1 antibody (MINT/1/4) serves as an invaluable tool for researchers investigating the complexities of Ras-mediated signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ksr-1 Antibody (MINT/1/4) References:
- KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. | Bell, B., et al. 1999. J Biol Chem. 274: 7982-6. PMID: 10075696
- Inflammatory bowel disease reveals the kinase activity of KSR1. | Kolesnick, R. and Xing, HR. 2004. J Clin Invest. 114: 1233-7. PMID: 15520853
- KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production. | Goettel, JA., et al. 2011. Gastroenterology. 140: 265-74. PMID: 20875416
- KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. | Goettel, JA., et al. 2011. Exp Cell Res. 317: 452-63. PMID: 21144847
- Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation. | Kortum, RL., et al. 2014. Mol Cell Biol. 34: 3461-72. PMID: 25002533
- KSR1 is coordinately regulated with Notch signaling and oxidative phosphorylation in thyroid cancer. | Lee, J., et al. 2015. J Mol Endocrinol. 54: 115-24. PMID: 25608512
- Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells. | Liu, Z., et al. 2023. Int J Mol Sci. 24: PMID: 37511580
- SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status. | Daley, BR., et al. 2023. Proc Natl Acad Sci U S A. 120: e2313137120. PMID: 37972068
- Development of Genetically Encoded Fluorescent KSR1-Based Probes to Track Ceramides during Phagocytosis. | Girik, V., et al. 2024. Int J Mol Sci. 25: PMID: 38474242
- KSR1 Knockout Mouse Model Demonstrates MAPK Pathway's Key Role in Cisplatin- and Noise-induced Hearing Loss. | Ingersoll, MA., et al. 2024. J Neurosci. 44: PMID: 38548338
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ksr-1 Antibody (MINT/1/4) | sc-56923 | 200 µg/ml | $322.00 |