Molecular structure of KRIBB11, CAS Number: 342639-96-7
KRIBB11 (CAS 342639-96-7)
Alternate Names:
N2-1H-indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine
CAS Number:
342639-96-7
Molecular Weight:
284.3
Molecular Formula:
C13H12N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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KRIBB11 (CAS 342639-96-7) References
- KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. | Yoon, YJ., et al. 2011. J Biol Chem. 286: 1737-47. PMID: 21078672
- Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis. | Antonietti, P., et al. 2017. Mol Cancer Ther. 16: 156-168. PMID: 27777286
- KRIBB11 accelerates Mcl-1 degradation through an HSF1-independent, Mule-dependent pathway in A549 non-small cell lung cancer cells. | Kang, MJ., et al. 2017. Biochem Biophys Res Commun. 492: 304-309. PMID: 28859986
- HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression. | Wang, Y., et al. 2021. Reprod Biol Endocrinol. 19: 86. PMID: 34107992
- KRIBB11 Induces Apoptosis in A172 Glioblastoma Cells via MULE-Dependent Degradation of MCL-1. | Yoo, K., et al. 2021. Molecules. 26: PMID: 34299435
- KRIBB11: A Promising Drug that Promotes Microglial Process Elongation and Suppresses Neuroinflammation. | Su, J., et al. 2022. Front Pharmacol. 13: 857081. PMID: 35370703
- HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program. | Huang, M., et al. 2022. Cancer Commun (Lond). 42: 447-470. PMID: 35434944
- A novel role of lactate: Promotion of Akt-dependent elongation of microglial process. | Hong, H., et al. 2023. Int Immunopharmacol. 119: 110136. PMID: 37075668
- Heat shock factor 1 is a promising therapeutic target against adult T-cell leukemia. | Ishikawa, C. and Mori, N. 2023. Med Oncol. 40: 172. PMID: 37165174
- Suppression of NSCLC progression via the co-administration of Danusertib, an AURK inhibitor, and KRIBB11, an HSF1 inhibitor. | Zhang, X., et al. 2024. Biochem Pharmacol. 223: 116155. PMID: 38521474
Inhibitor of:
β-2-Microglobulin, AI747448, Bag-3, CCT A, CLC-2, DNAAF3, DnaJC18, DRG1, Glut3, HSBP1, HSF1, HSF2, HSF3, HSF4, HSP 20, HSP 60, Kar2, P23, SLC26A8, and SLC26A9.Activator of:
HSPB11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KRIBB11, 5 mg | sc-507391 | 5 mg | $95.00 |