IL-3/IL-5/GM-CSFRβ Antibody (8E4): sc-21766
- IL-3/IL-5/GM-CSFRβ Antibody (8E4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against IL-3/IL-5/GM-CSFRβ of human origin
- recommended for detection of 130 kDa β chain common to IL-3R, IL-5R and GM-CSFR of human origin by IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-3/IL-5/GM-CSFRβ Antibody (8E4). These reagents are now offered in bundles with IL-3/IL-5/GM-CSFRβ Antibody (8E4) (see ordering information below).
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IL-3/IL-5/GM-CSFRβ Antibody (8E4) is a mouse monoclonal IgG1 antibody that detects interleukin-3/interleukin-5/granulocyte-macrophage colony-stimulating factor receptor beta (IL-3/IL-5/GM-CSFRβ) in human samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. IL-3/IL-5/GM-CSFRβ plays a crucial role in the immune system by serving as a receptor for the cytokines IL-3, IL-5, and GM-CSF, which are essential for the proliferation and differentiation of hematopoietic cells. The receptor is composed of a ligand-specific alpha subunit and a common beta subunit that is shared among the three cytokines. The beta subunit activates the MAP kinase signaling pathway, which is critical for cellular responses to these cytokines. Upon binding of IL-3, the receptor complex initiates a cascade of intracellular signaling events, including JAK2 kinase activation, leading to phosphorylation of transcription factors Stat5a and Stat5b. This process promotes cell survival, proliferation, and differentiation, particularly in hematopoietic progenitor cells. Anti-IL-3/IL-5/GM-CSFRβ antibody (8E4) serves as an invaluable tool for researchers studying hematopoiesis and immune responses, providing insights into cell signaling mechanisms and cytokine functional roles in health and disease.
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IL-3/IL-5/GM-CSFRβ Antibody (8E4) References:
- Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor. | Okuda, K., et al. 1999. Ann N Y Acad Sci. 872: 305-12; discussion 312-3. PMID: 10372132
- Inhibition of GM-CSF/IL-3/IL-5 signaling by antisense oligodeoxynucleotides targeting the common beta chain of their receptors. | Allam, M. and Renzi, PM. 2001. Antisense Nucleic Acid Drug Dev. 11: 289-300. PMID: 11763346
- Molecular structure of the IL-3, GM-CSF and IL-5 receptors. | Miyajima, A. 1992. Int J Cell Cloning. 10: 126-34. PMID: 1613263
- CD8(+) T cells producing IL-3 and IL-5 in non-IgE-mediated eosinophilic diseases. | Stoeckle, C. and Simon, HU. 2013. Allergy. 68: 1622-5. PMID: 24410785
- IL-3 and GM-CSF modulate functions of splenic macrophages in ENU induced leukemia. | Singha, AK., et al. 2017. Cytokine. 91: 89-95. PMID: 28039843
- Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. | Wang, H., et al. 2022. Cell Death Dis. 13: 137. PMID: 35145069
- A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. | Koochaki, SHJ., et al. 2022. J Biol Chem. 298: 102484. PMID: 36108743
- Role of IL-5 in asthma and airway remodelling. | AbuJabal, R., et al. 2024. Clin Exp Allergy. 54: 538-549. PMID: 38938056
- The influence of IL-3, IL-5, and GM-CSF on normal human eosinophil and neutrophil C3b-induced degranulation. | Carlson, M., et al. 1993. Allergy. 48: 437-42. PMID: 8238799
- Autocrine activation of the IL-3/GM-CSF/IL-5 signaling pathway in leukemic cells. | Paul, CC., et al. 1997. Am J Hematol. 56: 79-85. PMID: 9326348
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-3/IL-5/GM-CSFRβ Antibody (8E4) | sc-21766 | 200 µg/ml | $322.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4): m-IgG Fc BP-HRP Bundle | sc-536664 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4): m-IgGκ BP-HRP Bundle | sc-533823 | 200 µg Ab; 40 µg BP | $361.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4): m-IgG1 BP-HRP Bundle | sc-544748 | 200 µg Ab; 20 µg BP | $361.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4) FITC | sc-21766 FITC | 200 µg/ml | $336.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4) PE | sc-21766 PE | 200 µg/ml | $349.00 |