IFN-γRβ Antibody (2 HUB 159): sc-53589
- IFN-γRβ Antibody (2 HUB 159) is a Armenian hamster monoclonal IgG provided at 200 µg/ml
- raised against the extracellular domain of IFN-γRβ of human origin
- recommended for detection of IFN-γRβ of human origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γRβ Antibody (2 HUB 159). This work is in progress.
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IFN-γRβ Antibody (2 HUB 159) is a hamster monoclonal IgG antibody that detects IFN-γRβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). IFN-γRβ, also known as the signal transducing component of the interferon-gamma receptor, plays a crucial role in mediating the biological effects of interferon-gamma, including antiviral, antiproliferative, and immunomodulatory responses. IFN-γRβ is primarily located on the cell surface, where IFN-γRβ forms a functional receptor complex with IFN-γRα. Both chains are essential for receptor signal transduction, leading to downstream pathway activation that regulates gene expression in response to IFN-γ. IFN-γRβ interaction with Janus kinases (JAK1 and JAK2) upon ligand binding initiates phosphorylation events, resulting in nuclear translocation of transcription factors Stat1α and Stat1β. Understanding IFN-γRβ localization and function is vital, as IFN-γRβ underpins receptor role in immune responses and potential implications in various diseases, including autoimmune disorders and infections.
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IFN-γRβ Antibody (2 HUB 159) References:
- Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma. | Larkin, J., et al. 2000. J Interferon Cytokine Res. 20: 565-76. PMID: 10888113
- Interferon-gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death. | Bernabei, P., et al. 2001. J Leukoc Biol. 70: 950-60. PMID: 11739558
- Influence of a mutation in IFN-γ receptor 2 (IFNGR2) in human cells on the generation of Th17 cells in memory T cells. | Holzer, U., et al. 2013. Hum Immunol. 74: 693-700. PMID: 23459074
- IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk. | Jemli, A., et al. 2017. Nord J Psychiatry. 71: 42-47. PMID: 27563937
- Crystal structure of human interferon-γ receptor 2 reveals the structural basis for receptor specificity. | Mikulecký, P., et al. 2016. Acta Crystallogr D Struct Biol. 72: 1017-25. PMID: 27599734
- 1-Methyl-L-tryptophan promotes the apoptosis of hepatic stellate cells arrested by interferon-γ by increasing the expression of IFN-γRβ, IRF-1 and FAS. | Oh, JE., et al. 2017. Int J Mol Med. 40: 576-582. PMID: 28656203
- Identification of RUNX1 and IFNGR2 as prognostic-related biomarkers correlated with immune infiltration and subtype differentiation of low-grade glioma. | Zhang, X., et al. 2023. Biomol Biomed. 23: 405-425. PMID: 36321611
- Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis. | Bogers, L., et al. 2024. J Autoimmun. 148: 103279. PMID: 38972102
- Sézary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain). | Dummer, R., et al. 1996. Blood. 88: 1383-9. PMID: 8695857
- Sézary syndrome, T-helper 2 cytokines and accessory factor-1 (AF-1). | Dummer, R., et al. 1998. Leuk Lymphoma. 28: 515-22. PMID: 9613981
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γRβ Antibody (2 HUB 159) | sc-53589 | 200 µg/ml | $322.00 | |||
IFN-γRβ Antibody (2HUB-159) FITC | sc-53589 FITC | 200 µg/ml | $336.00 | |||
IFN-γRβ Antibody (2HUB-159) PE | sc-53589 PE | 200 µg/ml | $349.00 |