IFN-γ/Interferon gamma Antibody (LLO6Z): sc-74108
- IFN-γ/Interferon gamma Antibody (LLO6Z) is a mouse monoclonal IgG2b, cited in 4 publications, provided at 50 µg/0.5 ml
- raised against full length recombinant IFN-γ of human origin
- recommended for detection of IFN-γ of human origin by IF, IHC(P), FCM and ELISA
- See IFN-γ/Interferon gamma (E-10): sc-373727 for IFN-γ/Interferon gamma antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (LLO6Z). This work is in progress.
IFN-γ Antibody (LLO6Z) is a mouse monoclonal IgG2b antibody that detects interferon gamma (IFN-γ) in human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IFN-γ plays a crucial role in the immune response, acting as a potent antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. The importance of IFN-γ lies in its ability to modulate T cell growth and differentiation while inhibiting B cell proliferation, thereby orchestrating a balanced immune response. The protein′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ functionality is further enhanced by variable glycosylation, leading to multiple forms under non-denaturing conditions, including dimers and tetramers. The versatility of IFN-γ in mediating immune responses makes IFN-γ a critical target for research and therapeutic applications, and IFN-γ (LLO6Z) monoclonal antibody is an essential tool for studying its role in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFN-γ/Interferon gamma Antibody (LLO6Z) References:
- Expression of IFN-gamma in cerebrovascular endothelial cells from aged mice. | Wei, YP., et al. 2000. J Interferon Cytokine Res. 20: 403-9. PMID: 10805375
- Engineering of macrophages to produce IFN-gamma in response to hypoxia. | Carta, L., et al. 2001. J Immunol. 166: 5374-80. PMID: 11313373
- Actions of TNF and IFN-gamma on angiogenesis in vitro. | Sato, N., et al. 1990. J Invest Dermatol. 95: 85S-89S. PMID: 1701814
- Role of PKCdelta in IFN-gamma-inducible CIITA gene expression. | Kwon, MJ., et al. 2007. Mol Immunol. 44: 2841-9. PMID: 17346795
- IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability. | Hindinger, C., et al. 2012. PLoS One. 7: e42088. PMID: 22848713
- IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer. | Abiko, K., et al. 2015. Br J Cancer. 112: 1501-9. PMID: 25867264
- The role of IFN-γ in regulating Nfkbiz expression in epidermal keratinocytes. | Ishiguro-Oonuma, T., et al. 2015. Biomed Res. 36: 103-7. PMID: 25876660
- IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection. | Dolowschiak, T., et al. 2016. Cell Host Microbe. 20: 238-49. PMID: 27453483
- Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133). | Szente, BE., et al. 1995. J Immunol. 155: 5617-22. PMID: 7499845
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (LLO6Z) | sc-74108 | 50 µg/0.5 ml | $322.00 |