HIP2 Antibody (757C3a): sc-81286
- HIP2 Antibody (757C3a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the C-terminus of HIP2 of human origin
- recommended for detection of HIP2 isoforms 1 and 2 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HIP2 Antibody (757C3a). This work is in progress.
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HIP2 Antibody (757C3a) is a mouse monoclonal IgG1 antibody that detects HIP2 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. HIP2, a critical membrane-associated protein, interacts specifically with the N-terminus of human Huntingtin, playing a significant role in cellular processes. The importance of HIP2 lies in its involvement in maintaining membrane-cytoskeletal integrity, particularly in the context of Huntington′s disease. Research has shown that while the interaction between Huntingtin and HIP1 is inversely correlated with the polyglutamine length in Huntingtin, HIP2 binding remains unaffected by this length, indicating a distinct functional pathway. This unique characteristic of HIP2 suggests potential use as a therapeutic target or biomarker in the study of Huntington′s disease and related neurodegenerative disorders. HIP2 expression, along with Huntingtin interaction, underscores relevance in understanding the molecular mechanisms underlying neuronal health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIP2 Antibody (757C3a) | sc-81286 | 100 µg/ml | $339.00 |