Hck Antibody (E-1): sc-166402
- Hck Antibody (E-1) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-85 of Hck of human origin
- recommended for detection of Hck of human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Hck Antibody (E-1) for WB applications. This reagent is now offered in a bundle with Hck Antibody (E-1) (see ordering information below).
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Hck Antibody (E-1) is a mouse monoclonal IgG2b antibody that detects Hck in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Hck, or human hemopoietic cell kinase, plays a crucial role in the signaling pathways of hematopoietic cells, particularly in granulocytes, where Hck is abundantly expressed. Hck (E-1) antibody helps researchers study essential cellular processes, including cell proliferation, differentiation, and migration, which are vital for immune responses. Hck is localized primarily in the cytoplasm and can translocate to the cell membrane upon activation, highlighting Hck′s importance in modulating cellular signaling in response to external stimuli. Proper functioning of Hck is critical for maintaining immune homeostasis, and dysregulation of Hck activity has been implicated in various hematological disorders and cancers. Anti-Hck antibody (E-1) provides a reliable tool for researchers studying the intricate roles of this kinase in cellular signaling and its implications in health and disease.
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Hck Antibody (E-1) References:
- Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells. | Poh, AR., et al. 2015. Oncotarget. 6: 15752-71. PMID: 26087188
- Hck Promotes Neuronal Apoptosis Following Intracerebral Hemorrhage. | Wang, J., et al. 2017. Cell Mol Neurobiol. 37: 251-261. PMID: 27053350
- HCK promotes glioblastoma progression by TGFβ signaling. | Wang, Z., et al. 2020. Biosci Rep. 40: PMID: 32484210
- The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance. | Yang, G., et al. 2021. Blood. 138: 1966-1979. PMID: 34132782
- HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML. | Li, Z., et al. 2021. J Exp Clin Cancer Res. 40: 210. PMID: 34167558
- Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK. | Kanderova, V., et al. 2022. J Allergy Clin Immunol. 149: 1464-1472.e3. PMID: 34536415
- Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy. | Poh, AR., et al. 2022. Sci Adv. 8: eabl7882. PMID: 35731867
- Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis. | Poh, AR., et al. 2022. Cell Rep. 41: 111479. PMID: 36223746
- NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases. | Hu, C., et al. 2023. Am J Pathol. 193: 702-724. PMID: 36868467
- HCK Promotes High-Grade Serous Ovarian Cancer Tumorigenesis through CD44 and NOTCH3 Signaling. | Khella, CA., et al. 2023. Mol Cancer Res. 21: 1037-1049. PMID: 37342066
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hck Antibody (E-1) | sc-166402 | 200 µg/ml | $322.00 | |||
Hck Antibody (E-1): m-IgG2b BP-HRP Bundle | sc-548517 | 200 µg Ab; 10 µg BP | $361.00 |