GPI Antibody (1B7D7): sc-130067
- GPI Antibody (1B7D7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant full length GPI protein of human origin
- recommended for detection of GPI of human origin by WB, IP and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GPI Antibody (1B7D7) for WB applications. These reagents are now offered in bundles with GPI Antibody (1B7D7) (see ordering information below).
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GPI Antibody (1B7D7) is a mouse monoclonal IgG1 antibody that detects glucose-6-phosphate isomerase (GPI) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). GPI is a crucial enzyme that plays a significant role in both glycolysis and gluconeogenesis, processes essential for energy production and glucose homeostasis in the body. Anti-GPI antibody (1B7D7) targets a protein primarily located in the cytoplasm, where GPI functions as a homodimer, facilitating the interconversion of glucose-6-phosphate and fructose-6-phosphate. The proper functioning of GPI is vital, as defects or mutations in this enzyme can lead to serious health issues, including hereditary nonspherocytic hemolytic anemia, hydrops fetalis, and neurological impairments. GPI monoclonal antibody (1B7D7) provides a reliable tool for researchers studying these critical pathways and their implications in various diseases, enabling a deeper understanding of the molecular mechanisms at play.
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GPI Antibody (1B7D7) References:
- Glucose-6-phosphate isomerase promotes the proliferation and inhibits the apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis. | Zong, M., et al. 2015. Arthritis Res Ther. 17: 100. PMID: 25889507
- Enolase1 (ENO1) and glucose-6-phosphate isomerase (GPI) are good markers to predict human sperm freezability. | Jiang, XP., et al. 2015. Cryobiology. 71: 141-5. PMID: 25910678
- Genetic variants in glucose-6-phosphate isomerase gene as prognosis predictors in hepatocellular carcinoma. | Lyu, Z., et al. 2016. Clin Res Hepatol Gastroenterol. 40: 698-704. PMID: 27288297
- Glucose-6-Phosphate Isomerase (G6PI) Mediates Hypoxia-Induced Angiogenesis in Rheumatoid Arthritis. | Lu, Y., et al. 2017. Sci Rep. 7: 40274. PMID: 28067317
- Proteomics analysis of asthenozoospermia and identification of glucose-6-phosphate isomerase as an important enzyme for sperm motility. | Guo, Y., et al. 2019. J Proteomics. 208: 103478. PMID: 31394311
- Revisit of autoimmunity to glucose-6-phosphate isomerase in experimental and rheumatoid arthritis. | Matsumoto, I., et al. 2020. Mod Rheumatol. 30: 232-238. PMID: 31441345
- Glucose-6-phosphate isomerase is associated with disease activity and declines in response to infliximab treatment in rheumatoid arthritis. | Xu, J., et al. 2020. Chin Med J (Engl). 133: 886-891. PMID: 32187052
- Elevated Serum Glucose-6-Phosphate Isomerase Level in Patients with Knee Osteoarthritis. | Ji, X. and Bian, W. 2020. Clin Lab. 66: PMID: 33073968
- Glucose 6 Phosphate Isomerase Deficiency, a Rare Hemolytic Anemia Misdiagnosed as Hereditary Spherocytosis. | Gruda Sussman, R., et al. 2023. J Pediatr Hematol Oncol. 45: 41-43. PMID: 36161881
- RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32. | Wang, L., et al. 2023. Pharmacol Res. 198: 106995. PMID: 37979663
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GPI Antibody (1B7D7) | sc-130067 | 200 µg/ml | $322.00 | |||
GPI Antibody (1B7D7): m-IgG Fc BP-HRP Bundle | sc-539804 | 200 µg Ab; 10 µg BP | $361.00 | |||
GPI Antibody (1B7D7): m-IgG1 BP-HRP Bundle | sc-541721 | 200 µg Ab; 20 µg BP | $361.00 |