Glyoxalase I Antibody (GloIa): sc-101877
- Glyoxalase I Antibody (GloIa) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against full-length Glyoxalase I of human origin
- recommended for detection of Glyoxalase I of mouse, rat and human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Glyoxalase I Antibody (GloIa) for WB applications. These reagents are now offered in bundles with Glyoxalase I Antibody (GloIa) (see ordering information below).
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Glyoxalase I Antibody (GloIa) is a mouse monoclonal IgG1 antibody that detects Glyoxalase I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Glyoxalase I plays a crucial role in the detoxification of glucose degradation products, specifically through the glyoxalase pathway, which is vital for cellular health and metabolic balance. This enzyme helps mitigate the harmful effects of reactive carbonyl species, which can lead to cellular stress and contribute to various diseases, including diabetes and neurodegenerative disorders. Glyoxalase I exists in three isoforms, generated from two alleles, forming two homodimers and one heterodimer, with each subunit binding a zinc ion, which is essential for enzymatic activity. GLO1 gene expression has been shown to be induced in colon carcinoma, highlighting a potential role in cancer biology. Additionally, the presence of an insulin response element and a zinc metal response element in the promoter region of the GLO1 gene suggests regulation is intricately linked to metabolic states and cellular responses to stress, making Glyoxalase I a significant target for research in both metabolic and cancer-related studies. Anti-Glyoxalase I antibody (GloIa) serves as an invaluable tool for researchers exploring the functional dynamics of this important protein in various biological contexts.
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Glyoxalase I Antibody (GloIa) References:
- Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycation. | Thornalley, PJ. 2003. Biochem Soc Trans. 31: 1343-8. PMID: 14641060
- Glyoxalase I in tumor cell proliferation and survival and as a potential target for anticancer therapy. | Geng, X., et al. 2014. Oncol Res Treat. 37: 570-4. PMID: 25342507
- Role of glyoxalase I gene polymorphisms in late-onset epilepsy and drug-resistant epilepsy. | Tao, H., et al. 2016. J Neurol Sci. 363: 200-6. PMID: 27000251
- Novel glyoxalase-I inhibitors possessing a 'zinc-binding feature' as potential anticancer agents. | Al-Balas, QA., et al. 2016. Drug Des Devel Ther. 10: 2623-9. PMID: 27574401
- Expression analysis of glyoxalase I gene among patients of diabetic retinopathy. | Rasul, A., et al. 2018. Pak J Med Sci. 34: 139-143. PMID: 29643895
- Dissecting the Physiological Function of Plant Glyoxalase I and Glyoxalase I-Like Proteins. | Schmitz, J., et al. 2018. Front Plant Sci. 9: 1618. PMID: 30483284
- Recent advances in the discovery and development of glyoxalase I inhibitors. | Jin, T., et al. 2020. Bioorg Med Chem. 28: 115243. PMID: 31879183
- Dimeric phosphorylation of glyoxalase I alters its symmetry and substrate binding mechanism: simulation studies. | Barber, LM., et al. 2022. J Biomol Struct Dyn. 40: 5687-5701. PMID: 33459186
- Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. | Usami, M., et al. 2022. FEBS Lett. 596: 1458-1467. PMID: 35363883
- Nordihydroguaiaretic acid inhibits glyoxalase I, and causes the accumulation of methylglyoxal followed by cell-growth inhibition. | Watanabe, M., et al. 2022. Mol Biol Rep. 49: 10499-10507. PMID: 36127524
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glyoxalase I Antibody (GloIa) | sc-101877 | 200 µg/ml | $322.00 | |||
Glyoxalase I Antibody (GloIa): m-IgG Fc BP-HRP Bundle | sc-537312 | 200 µg Ab; 10 µg BP | $361.00 | |||
Glyoxalase I Antibody (GloIa): m-IgGκ BP-HRP Bundle | sc-534547 | 200 µg Ab; 40 µg BP | $361.00 | |||
Glyoxalase I Antibody (GloIa) FITC | sc-101877 FITC | 200 µg/ml | $336.00 | |||
Glyoxalase I Antibody (GloIa) PE | sc-101877 PE | 200 µg/ml | $349.00 |