Date published: 2026-6-3
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Glyoxalase I Antibody (G-6) - Western Blotting - Image 380677
Glyoxalase I Antibody (G-6): sc-133213. Western blot analysis of Glyoxalase I expression in HEL 92.1.7 (A), Caki-1 (B) and PC-12 (C) whole cell lysates.
Glyoxalase I Antibody (G-6): sc-133213. Western blot analysis of Glyoxalase I expression in HEL 92.1.7 (A), Caki-1 (B) and PC-12 (C) whole cell lysates.

Glyoxalase I Antibody (G-6): sc-133213

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Datasheets
  • Glyoxalase I Antibody (G-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
  • raised against amino acids 1-184 representing full length Glyoxalase I of human origin
  • recommended for detection of Glyoxalase I of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Glyoxalase I Antibody (G-6) for WB and IHC(P) applications. These reagents are now offered in bundles with Glyoxalase I Antibody (G-6) (see ordering information below).
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    Additional Glyoxalase Antibodies including Glyoxalase II

    Glyoxalase I Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects Glyoxalase I in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Glyoxalase I (GLO1) plays a crucial role in the detoxification of glucose degradation products, which is vital for cellular health and metabolic balance. GLO1 helps mitigate the harmful effects of reactive carbonyl species arising from glucose metabolism during oxidative stress. GLO1 exists in three isoforms, generated from two alleles in the genome, forming two homodimers and one heterodimer, with each subunit binding a zinc ion essential for enzymatic activity. GLO1 expression has been shown to be induced in colon carcinoma, highlighting its potential role in cancer biology. The presence of an insulin response element and a zinc metal response element in the GLO1 gene promoter region suggests expression regulation by metabolic signals, making anti-GLO1 antibody (G-6) a valuable tool for research in metabolic disorders and cancer.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Glyoxalase I Antibody (G-6) References:

    1. Purification of glyoxalase I from onion bulbs and molecular cloning of its cDNA.  |  Hossain, MA. and Fujita, M. 2009. Biosci Biotechnol Biochem. 73: 2007-13. PMID: 19734676
    2. Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy.  |  Jack, M. and Wright, D. 2012. Transl Res. 159: 355-65. PMID: 22500508
    3. Design, Synthesis and Biological Evaluation of Potent Human Glyoxalase I Inhibitors.  |  Jin, T., et al. 2017. Chem Pharm Bull (Tokyo). 65: 455-460. PMID: 28320998
    4. Inhibition of Glyoxalase-I Leads to Reduced Proliferation, Migration and Colony Formation, and Enhanced Susceptibility to Sorafenib in Hepatocellular Carcinoma.  |  Michel, M., et al. 2019. Front Oncol. 9: 785. PMID: 31482070
    5. Common variants in glyoxalase I do not increase chronic pancreatitis risk.  |  Kaune, T., et al. 2019. PLoS One. 14: e0222927. PMID: 31661534
    6. Two-Substrate Glyoxalase I Mechanism: A Quantum Mechanics/Molecular Mechanics Study.  |  Jafari, S., et al. 2021. Inorg Chem. 60: 303-314. PMID: 33315368
    7. Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons.  |  Hara, T., et al. 2021. Transl Psychiatry. 11: 275. PMID: 33966051
    8. Lead optimization and biological evaluation of diazenylbenzenesulfonamides inhibitors against glyoxalase-I enzyme as potential anticancer agents.  |  Al-Oudat, BA., et al. 2022. Bioorg Chem. 120: 105657. PMID: 35152183
    9. Unraveling Potential Glyoxalase-I Inhibitors Utilizing Structure-Based Drug Design Techniques.  |  Fetian, MH. and Al-Balas, QA. 2024. Adv Appl Bioinform Chem. 17: 21-32. PMID: 38343400
    10. Effect of radiation on glyoxalase I and glyoxalase II activities in spleen and liver of mice.  |  Sharma, R. and Kale, RK. 1993. Int J Radiat Biol. 63: 233-8. PMID: 8094420

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Glyoxalase I Antibody (G-6)

    sc-133213
    200 µg/ml
    		$322.00

    Glyoxalase I Antibody (G-6): m-IgG Fc BP-HRP Bundle

    sc-537356
    200 µg Ab; 10 µg BP
    		$361.00

    Glyoxalase I Antibody (G-6): m-IgGκ BP-HRP Bundle

    sc-534601
    200 µg Ab; 40 µg BP
    		$361.00

    Glyoxalase I Antibody (G-6): m-IgG1 BP-HRP Bundle

    sc-545153
    200 µg Ab; 20 µg BP
    		$361.00

    Can Glyoxalase I (G-6): sc-133213 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Asked by: DefinitelyNotMatt
    Thank you for your question. Yes, Glyoxalase I (G-6): sc-133213 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Great immunoperoxidase cytoplasmic and nuclearGreat immunoperoxidase cytoplasmic and nuclear staining in formalin fixed, paraffin-embedded human prostate tissue. -SCBT QC
    Date published: 2015-05-06
    Rated 5 out of 5 by from Nice Western Blot data of Glyoxalase I expressionNice Western Blot data of Glyoxalase I expression in 293 whole cell lysate. -SCBT QC
    Date published: 2013-05-14
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    Glyoxalase I Antibody (G-6) is rated 5.0 out of 5 by 2.
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