galectin-7 Antibody (H-8): sc-166222

galectin-7 Antibody (H-8) is a mouse monoclonal IgG2b antibody that detects galectin-7 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Galectin-7 is a member of the galectin family, which consists of soluble β-galactoside-binding lectins that play crucial roles in cellular processes such as cell adhesion, apoptosis, and tumor progression. Galectin-7 is predominantly expressed in stratified squamous epithelium and is known for its pro-apoptotic function, acting upstream of c-Jun N-terminal kinase (JNK) activation and cytochrome c release, which are vital for the apoptotic signaling pathway. Galectin-7 regulation is tightly controlled, as anti-galectin-7 antibody (H-8) shows activation by p53 and repression by retinoic acid, highlighting its importance in maintaining cellular homeostasis and responding to stress signals. The galectin-7 gene is located on chromosome 19, and galectin-7 interactions with other proteins can influence various cellular outcomes, making galectin-7 a significant target for research in cancer biology and therapeutic development. Anti-galectin-7 antibody (H-8) provides a reliable tool for studying the expression and function of galectin-7 in various biological contexts.

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galectin-7 Antibody (H-8) References:

1. Galectin-7 is important for normal uterine repair following menstruation.  |  Evans, J., et al. 2014. Mol Hum Reprod. 20: 787-98. PMID: 24782449
2. Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment.  |  Higareda-Almaraz, JC., et al. 2016. BMC Cancer. 16: 680. PMID: 27558259
3. Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer.  |  Grosset, AA., et al. 2016. PLoS One. 11: e0166731. PMID: 27902734
4. Galectin-7 is elevated in endometrioid (type I) endometrial cancer and promotes cell migration.  |  Menkhorst, E., et al. 2018. Oncol Lett. 16: 4721-4728. PMID: 30250540
5. Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.  |  Umayahara, T., et al. 2020. Clin Exp Allergy. 50: 922-931. PMID: 32474952
6. Galectin-7 promotes proliferation and wound healing capacities in periodontal ligament fibroblasts by activating ERK signaling.  |  Huang, CY., et al. 2022. J Formos Med Assoc. 121: 1008-1011. PMID: 34452782
7. Generation of DNA-aptamers targeting galectin-7 for the identification of cholesteatoma residue.  |  Liu, S., et al. 2022. J Pharmacol Sci. 150: 146-153. PMID: 36184119
8. Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions.  |  Liang, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36293173
9. Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression.  |  An, J., et al. 2022. Oncogene. 41: 5319-5330. PMID: 36335283
10. Galectin-7 Expression in the Placentas of Women with Gestational Diabetes Mellitus.  |  Seifert, CT., et al. 2024. Int J Mol Sci. 25: PMID: 39337670

The preferred galectin-7 antibody is galectin-7 Antibody (G-3): sc-137085.