Fibrinogen α Antibody (471CT12.1.2): sc-517331

Fibrinogen α Antibody (471CT12.1.2) is a mouse monoclonal IgM antibody that detects Fibrinogen α in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Fibrinogen α is one of the three subunits of the plasma glycoprotein Fibrinogen, which plays a crucial role in the coagulation cascade, particularly in the formation of Fibrin, the primary component of blood clots. Fibrinogen α is synthesized in the liver and is essential for platelet aggregation, which is vital for hemostasis following tissue injury. Upon vascular damage, Fibrinogen α is cleaved by Thrombin, resulting in the formation of Fibrin, which not only serves as a scaffold for clot formation but also regulates cell adhesion and spreading, exhibits vasoconstrictor and chemotactic properties, and acts as a mitogen for various cell types. Anti-Fibrinogen α antibody (471CT12.1.2) serves as a valuable tool for researchers studying coagulation and related processes, as Fibrinogen α interactions with other coagulation factors and role in the acute phase response highlight its importance in maintaining hemostatic balance and responding to injury.

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Fibrinogen α Antibody (471CT12.1.2) References:

1. Role of fibrinogen alpha and gamma chain sites in platelet aggregation.  |  Farrell, DH., et al. 1992. Proc Natl Acad Sci U S A. 89: 10729-32. PMID: 1438269
2. Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits.  |  Fu, Y., et al. 1992. Biochemistry. 31: 11968-72. PMID: 1457396
3. Declining plasma fibrinogen alpha fragment identifies HER2-positive breast cancer patients and reverts to normal levels after surgery.  |  Shi, Q., et al. 2006. J Proteome Res. 5: 2947-55. PMID: 17081046
4. The monoclonal antibody that recognizes an epitope in the C-terminal region of the fibrinogen alpha-chain reacts with soluble fibrin and fibrin monomer generated by thrombin but not with those formed as plasmin degradation products.  |  Suzuki, A., et al. 2007. Thromb Res. 121: 377-85. PMID: 17561232
5. A synthetic analog of fibrinogen alpha 27-50 is an inhibitor of thrombin.  |  Binnie, CG. and Lord, ST. 1991. Thromb Haemost. 65: 165-8. PMID: 2053103
6. The measurement of a fibrinogen α C-chain 5.9 kDa fragment (FIC 5.9) using MALDI-TOF MS and a stable isotope-labeled peptide standard dilution.  |  Sogawa, K., et al. 2011. Clin Chim Acta. 412: 1094-9. PMID: 21354123
7. Lack of a 5.9 kDa peptide C-terminal fragment of fibrinogen α chain precedes fibrosis progression in patients with liver disease.  |  Marfà, S., et al. 2014. PLoS One. 9: e109254. PMID: 25275549
8. Irreversible platelet fibrinogen interactions occur independently of fibrinogen alpha chain degradation and are not mediated by intact platelet membrane glycoprotein IIb-IIIa complexes.  |  Peerschke, EI. 1988. J Lab Clin Med. 111: 84-92. PMID: 2826623
9. Effects of hypophysectomy of liver donor on net synthesis of specific plasma proteins by the isolated perfused rat liver. Modulation of synthesis of albumin, fibrinogen, alpha 1-acid glycoprotein, alpha 2-(acute phase)-globulin, and haptoglobin by insulin, cortisol, triiodothyronine, and growth hormone.  |  Griffin, EE. and Miller, LL. 1974. J Biol Chem. 249: 5062-9. PMID: 4211972
10. Comparative structural and functional features of the human fibrinogen alpha C domain and the isolated alpha C fragment. Characterization using monoclonal antibodies to defined COOH-terminal A alpha chain regions.  |  Rudchenko, S., et al. 1996. J Biol Chem. 271: 2523-30. PMID: 8576216

The preferred Fibrinogen α antibody is Fibrinogen α Antibody (C-7): sc-398806.