ES-D3 Whole Cell Lysate: sc-364776

ES-D3 whole cell lysate is derived from the ES-D3 cell line, an embryonic stem cell line from mice, predominantly used in developmental biology and regenerative medicine research to understand stem cell differentiation and pluripotency mechanisms. This lysate provides critical insights into the signaling pathways that regulate stem cell fate, such as the Wnt, Notch, and BMP pathways, which are crucial for maintaining stem cell characteristics or driving differentiation into various cell types. Researchers utilize ES-D3 lysate to explore how these cells respond to different biochemical signals and the intrinsic mechanisms that control gene expression during cell differentiation processes. It's especially useful in examining the role of transcription factors like Oct4, Sox2, and Nanog, which are pivotal in maintaining the pluripotent state. Additionally, this lysate allows for the study of cellular responses to external stimuli that mimic developmental cues, providing a model for understanding early embryonic development and potential applications in disease modeling. By using ES-D3 lysate, scientists aim to elucidate the complex molecular interactions that govern cell behavior in developmental biology, strictly within a research context, contributing to a broader understanding of cellular development processes.

ES-D3 Whole Cell Lysate Literaturhinweise:

1. Aus embryonalen Stammzellen stammende Mikrovesikel programmieren hämatopoetische Vorläuferzellen: Nachweis für horizontalen Transfer von mRNA und Proteinlieferung.  |  Ratajczak, J., et al. 2006. Leukemia. 20: 847-56. PMID: 16453000
2. Androgene und antiandrogene Wirkungen und Expression des Androgenrezeptors in embryonalen Stammzellen der Maus.  |  Chang, CY., et al. 2006. Fertil Steril. 85 Suppl 1: 1195-203. PMID: 16616092