ErbB4/HER4 Antibody (6C5): sc-81456
- ErbB4/HER4 Antibody (6C5) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1230-1250 of ErbB-4 of human origin
- recommended for detection of ErbB-4 of human origin by WB and IP
- See ErbB4/HER4 (C-7): sc-8050 for ErbB4/HER4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ErbB4/HER4 Antibody (6C5). This work is in progress.
ErbB-4 Antibody (6C5) is a mouse monoclonal IgG1 antibody that detects ErbB-4 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). ErbB-4 is a member of the epidermal growth factor receptor (EGFR) family, which plays a crucial role in cell signaling pathways that regulate cell proliferation, differentiation, and survival. Anti-ErbB-4 antibody (6C5) recognizes a protein primarily located on the cell membrane, where ErbB-4 can form homodimers or heterodimers upon ligand binding, leading to activation of its intrinsic tyrosine kinase activity. Notably, ErbB-4 undergoes proteolytic cleavage upon binding to its ligand, heregulin, resulting in the release of a soluble ectodomain that can further influence cellular signaling. ErbB-4 expression is highest in tissues such as normal skeletal muscle, heart, pituitary, brain, and cerebellum, highlighting its importance in both normal physiology and pathological conditions. With ErbB-4′s ability to facilitate critical cellular processes and involvement in various cancers, including breast carcinoma where ErbB-4 is often overexpressed, ErbB-4 (6C5) antibody serves as an essential tool for researchers studying this receptor′s role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ErbB4/HER4 Antibody (6C5) References:
- Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. | Tang, CK., et al. 1999. Cancer Res. 59: 5315-22. PMID: 10537315
- c-erbB-4 protein expression in human breast cancer. | Kew, TY., et al. 2000. Br J Cancer. 82: 1163-70. PMID: 10735500
- Heregulin-dependent trafficking and cleavage of ErbB-4. | Zhou, W. and Carpenter, G. 2000. J Biol Chem. 275: 34737-43. PMID: 10944525
- Closed head injury induces up-regulation of ErbB-4 receptor at the site of injury. | Erlich, S., et al. 2000. Mol Cell Neurosci. 16: 597-608. PMID: 11083921
- Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment. | Arasada, RR. and Carpenter, G. 2005. J Biol Chem. 280: 30783-7. PMID: 15985438
- Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets. | Ferretti, E., et al. 2006. Oncogene. 25: 7267-73. PMID: 16878160
- A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis. | Lindzen, M., et al. 2012. Oncogene. 31: 3505-15. PMID: 22105361
- Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2. | Beerli, RR., et al. 1995. Mol Cell Biol. 15: 6496-505. PMID: 8524214
- Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation. | Vecchi, M., et al. 1996. J Biol Chem. 271: 18989-95. PMID: 8702564
- Amplification of erbB-4 oncogene occurs less frequently than that of erbB-2 in primary human breast cancer. | Vogt, U., et al. 1998. Gene. 223: 375-80. PMID: 9858771
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ErbB4/HER4 Antibody (6C5) | sc-81456 | 50 µg/0.5 ml | $322.00 |