Endophilin I Antibody (B-1): sc-374279

Endophilin I Antibody (B-1) is a mouse monoclonal IgG2b antibody that detects Endophilin I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Endophilin I plays a crucial role in the regulation of synaptic vesicle trafficking at nerve terminals, which is essential for proper neurotransmission and communication between neurons. Endophilin I is primarily localized in the brain, where anti-Endophilin I antibody (B-1) can detect its involvement in the modulation of G protein-coupled receptor signaling by acting as an adapter protein that directs β1 adrenergic receptors to the endocytic machinery, thereby influencing receptor recycling and degradation. The interaction of Endophilin I with other proteins, such as Amphiphysin and Dynamin, highlights its importance in the endocytic pathway, making Endophilin I a key player in maintaining synaptic function and plasticity. Endophilin I monoclonal antibody (B-1) is an invaluable tool for researchers studying synaptic dynamics and the molecular mechanisms underlying neuronal communication.

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Endophilin I Antibody (B-1) References:

1. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.  |  Schmidt, A., et al. 1999. Nature. 401: 133-41. PMID: 10490020
2. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.  |  Howard, L., et al. 1999. J Biol Chem. 274: 31693-9. PMID: 10531379
3. Differential expression of endophilin 1 and 2 dimers at central nervous system synapses.  |  Ringstad, N., et al. 2001. J Biol Chem. 276: 40424-30. PMID: 11518713
4. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis.  |  Anggono, V. and Robinson, PJ. 2007. J Neurochem. 102: 931-43. PMID: 17437541
5. Endophilin I expression is increased in the brains of Alzheimer disease patients.  |  Ren, Y., et al. 2008. J Biol Chem. 283: 5685-91. PMID: 18167351
6. Structure-based characterization of the binding of peptide to the human endophilin-1 Src homology 3 domain using position-dependent noncovalent potential analysis.  |  Fu, C., et al. 2012. J Mol Model. 18: 2153-61. PMID: 21947444
7. Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway.  |  Liu, W., et al. 2014. Brain Res. 1573: 17-26. PMID: 24854121
8. Endophilin-1 regulates blood-brain barrier permeability via EGFR-JNK signaling pathway.  |  Chen, L., et al. 2015. Brain Res. 1606: 44-53. PMID: 25721793
9. MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1.  |  Liu, W., et al. 2016. Exp Cell Res. 343: 248-257. PMID: 27038654
10. Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β.  |  Yin, Y., et al. 2019. Mol Med Rep. 19: 4897-4905. PMID: 31059028

The preferred Endophilin I antibody is Endophilin I Antibody (D-3): sc-48378.