Dia 2 Antibody (C-7): sc-55540

Dia 2 Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects Dia 2 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Dia 2, also known as DIAPH2 or mDia3, is a critical member of the formin family of proteins, which play a vital role in regulating actin dynamics within cells. Dia 2 (C-7) antibody targets a protein primarily located in the cytoplasm that′s essential for forming and elongating actin filaments, crucial for cell motility, division, and shape maintenance. Dia 2 monoclonal antibody (C-7) recognizes a protein particularly important in reproductive tissues, as Dia 2 has been implicated in oogenesis and is expressed in testis and ovary. Mutations or defects in the gene encoding Dia 2 have been associated with premature ovarian failure type 2A, a condition leading to reduced ovarian function and fertility issues. Dia 2 exists in three alternatively spliced isoforms, which may have distinct regulatory roles in cellular processes. Through interactions with Rho GTPases and other signaling molecules, anti-Dia 2 antibody (C-7) helps researchers study a key player in cellular signaling pathways, making this tool invaluable for investigating actin dynamics and related disorders.

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Dia 2 Antibody (C-7) References:

1. The F-box protein Dia2 regulates DNA replication.  |  Koepp, DM., et al. 2006. Mol Biol Cell. 17: 1540-8. PMID: 16421250
2. Yra1 is required for S phase entry and affects Dia2 binding to replication origins.  |  Swaminathan, S., et al. 2007. Mol Cell Biol. 27: 4674-84. PMID: 17452447
3. Involvements of a novel protein, DIA2, in cAMP signaling and spore differentiation during Dictyostelium development.  |  Hirata, K., et al. 2008. Differentiation. 76: 310-22. PMID: 17825085
4. Activation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2.  |  Kile, AC. and Koepp, DM. 2010. Mol Cell Biol. 30: 160-71. PMID: 19858292
5. The amino-terminal TPR domain of Dia2 tethers SCF(Dia2) to the replisome progression complex.  |  Morohashi, H., et al. 2009. Curr Biol. 19: 1943-9. PMID: 19913425
6. Dia2 controls transcription by mediating assembly of the RSC complex.  |  Andress, EJ., et al. 2011. PLoS One. 6: e21172. PMID: 21701592
7. Hect E3 ubiquitin ligase Tom1 controls Dia2 degradation during the cell cycle.  |  Kim, DH. and Koepp, DM. 2012. Mol Biol Cell. 23: 4203-11. PMID: 22933573
8. DIA-2, a polyherbal formulation ameliorates hyperglycemia and protein-oxidation without increasing the body weight in type II diabetic rats.  |  Kesavanarayanan, KS., et al. 2013. Eur Rev Med Pharmacol Sci. 17: 356-69. PMID: 23426539
9. Herbal formulation, DIA-2 and Rosiglitazone ameliorates hyperglycemia and hepatic steatosis in type 2 diabetic rats.  |  Kesavanarayanan, KS., et al. 2015. Eur Rev Med Pharmacol Sci. 19: 3107-17. PMID: 26367735
10. Underexpression of a novel gene, dia2, impairs the transition of Dictyostelium cells from growth to differentiation.  |  Chae, SC., et al. 1998. Biochem Biophys Res Commun. 252: 278-83. PMID: 9813183

The preferred Dia 2 antibody is Dia 2 Antibody (H-3): sc-393489.