Cytokeratin 18 Antibody (2X44): sc-70917
- Cytokeratin 18 Antibody (2X44) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against cytokeratins from the human bladder carcinoma cell line T24
- recommended for detection of Cytokeratin 18 of human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Cytokeratin 18 (RGE53): sc-32329 for Cytokeratin 18 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Cytokeratin 18 Antibody (2X44) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 18 Antibody (2X44) (see ordering information below).
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Cytokeratin 18 Antibody (2X44) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 18 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Cytokeratin 18 is a vital component of the cytoskeleton in epithelial cells, contributing significantly to structural integrity and resilience. Cytokeratin 18 is predominantly located in the cytoplasm, forming a network of intermediate filaments that provide mechanical support and shape to cells. Proper localization of Cytokeratin 18 is crucial for maintaining epithelial tissue architecture, and disruption can lead to various pathological conditions, including cancer. Cytokeratin 18 serves as a biomarker for epithelial-derived tumors, as expression levels can indicate differentiation status of malignant cells. Post-translational modifications of Cytokeratin 18, such as phosphorylation, can influence interactions with other proteins and overall function within cells. Anti-Cytokeratin 18 antibody (2X44) enables researchers to explore epithelial biology and cancer pathology, advancing understanding of this protein′s role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cytokeratin 18 Antibody (2X44) References:
- Detection of epithelial cell death in the body by cytokeratin 18 measurement. | Ueno, T., et al. 2005. Biomed Pharmacother. 59 Suppl 2: S359-62. PMID: 16507409
- Increased total cytokeratin-18 serum and urine levels in chronic kidney disease. | Roth, GA., et al. 2011. Clin Chim Acta. 412: 713-7. PMID: 21195700
- Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease. | Świderska, M., et al. 2017. Mediators Inflamm. 2017: 3480234. PMID: 28827897
- Subacute Elevation of Plasma Level of Caspase-Cleaved Cytokeratin-18 is Associated with Hemorrhagic Transformation and Functional Outcome in Ischemic Stroke. | Molnar, T., et al. 2019. J Stroke Cerebrovasc Dis. 28: 719-727. PMID: 30528602
- Downregulation of cytokeratin 18 induces cellular partial EMT and stemness through increasing EpCAM expression in breast cancer. | Shi, R., et al. 2020. Cell Signal. 76: 109810. PMID: 33069797
- Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography: A prospective study. | Alhinai, A., et al. 2021. World J Hepatol. 13: 2179-2191. PMID: 35070018
- A new detection system for serum fragmented cytokeratin 18 as a biomarker reflecting histologic activities of human nonalcoholic steatohepatitis. | Eguchi, A., et al. 2022. Hepatol Commun. 6: 1987-1999. PMID: 35485207
- Serum Cytokeratin 18 Fragment Is an Indicator for Treating Metabolic Dysfunction-Associated Steatotic Liver Disease. | Kawanaka, M., et al. 2024. Gastro Hep Adv. 3: 1120-1128. PMID: 39533978
- Cytokeratin 18 is an M-cell marker in porcine Peyer's patches. | Gebert, A., et al. 1994. Cell Tissue Res. 276: 213-21. PMID: 7517344
- Cytokeratin 18 expression in squamous cell carcinoma of the head and neck. | Balm, AJ., et al. 1996. Eur Arch Otorhinolaryngol. 253: 227-33. PMID: 8737774
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 18 Antibody (2X44) | sc-70917 | 200 µg/ml | $322.00 | |||
Cytokeratin 18 Antibody (2X44): m-IgG Fc BP-HRP Bundle | sc-539322 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cytokeratin 18 Antibody (2X44): m-IgG1 BP-HRP Bundle | sc-541408 | 200 µg Ab; 20 µg BP | $361.00 | |||
Cytokeratin 18 Antibody (2X44) FITC | sc-70917 FITC | 200 µg/ml | $336.00 | |||
Cytokeratin 18 Antibody (2X44) PE | sc-70917 PE | 200 µg/ml | $349.00 |