CYP2B1/2B2 Antibody (9.14): sc-73546

CYP2B10 Antibody (9.14) is a mouse monoclonal IgG1 kappa light chain antibody that detects CYP2B10 protein of mouse origin and CYP2B1 and CYP2B2 proteins of rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-CYP2B10 antibody (9.14) is available as a non-conjugated format. CYP2B10 is a member of the cytochrome P450 superfamily, which plays a crucial role in metabolizing various endogenous and exogenous compounds, including drugs and fatty acids. CYP2B10 monoclonal antibody (9.14) recognizes a protein involved in the oxidative metabolism of several therapeutic agents, contributing to their activation or detoxification. CYP2B10 is predominantly expressed in the liver, where CYP2B10 participates in xenobiotic biotransformation, influencing drug efficacy and toxicity. Liver localization of CYP2B10 serves as a primary site for drug metabolism, impacting pharmacokinetics and overall therapeutic outcomes. Understanding CYP2B10 function and expression is essential for drug development and personalized medicine, as variations in CYP2B10 activity can lead to significant differences in drug response among individuals.

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CYP2B1/2B2 Antibody (9.14) References:

1. Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness.  |  Paquet, Y., et al. 2000. J Biol Chem. 275: 38427-36. PMID: 10993889
2. Functional analysis of the phenobarbital-responsive unit in rat CYP2B2.  |  Liu, S., et al. 2001. Biochem Pharmacol. 62: 21-8. PMID: 11377393
3. The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX-PREP1, the thyroid hormone receptor beta and the liver X receptor.  |  Beaudet, MJ., et al. 2005. Biochem J. 388: 407-18. PMID: 15656786
4. Peritoneal cancer treatment with CYP2B1 transfected, microencapsulated cells and ifosfamide.  |  Samel, S., et al. 2006. Cancer Gene Ther. 13: 65-73. PMID: 16096652
5. Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.  |  Chang, TK., et al. 2006. Drug Metab Dispos. 34: 234-42. PMID: 16258077
6. Styrene monomer primarily induces CYP2B1 mRNA in rat liver.  |  Hirasawa, F., et al. 2005. Xenobiotica. 35: 1089-99. PMID: 16418063
7. Effect of sulfur dioxide inhalation on CYP2B1/2 and CYP2E1 in rat liver and lung.  |  Qin, G. and Meng, Z. 2006. Inhal Toxicol. 18: 581-8. PMID: 16717030
8. Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.  |  Zhang, Q., et al. 2006. Arch Biochem Biophys. 451: 119-27. PMID: 16725103
9. RAT CYP3A and CYP2B1/2 were not associated with nevirapine-induced hepatotoxicity.  |  Walubo, A., et al. 2006. Methods Find Exp Clin Pharmacol. 28: 423-31. PMID: 17003847
10. mmu-miR-199a-5p regulates CYP2B10 through repression of E4BP4 in mouse AML-12 hepatocytes.  |  Ren, S., et al. 2021. Xenobiotica. 51: 1101-1109. PMID: 34382487
11. Period 2 Regulates CYP2B10 Expression and Activity in Mouse Liver.  |  Chen, M., et al. 2021. Front Pharmacol. 12: 764124. PMID: 34887762
12. Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute-on-chronic alcohol-induced liver injury.  |  Mackowiak, B., et al. 2022. Alcohol Clin Exp Res. 46: 2163-2176. PMID: 36224745

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CYP2B1/2B2 Antibody (9.14) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-CYP2B1/2B2 Antibody (9.14) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CYP2B1/2B2 Antibody (9.14) Specifications

Alternate Product Name: CYP2B1/2B2

Product Clone Name: 9.14

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: liver cytochrome P4502B1 and 2B2

Epitope Species: rat

Product Reactivity/Detection: CYP2B10 of mouse origin, and CYP2B1 and CYP2B2 of rat origin

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for CYP2B1/2B2 Antibody (9.14): N/A