cyclin B2 Antibody (X29.2): sc-53240
- cyclin B2 Antibody (X29.2) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against Xenopus cyclin B2
- recommended for detection of cyclin B2 of mouse, rat, human and Xenopus origin by WB and IP; may cross-react with cyclin B1 and other cyclin Bs
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cyclin B2 Antibody (X29.2) for WB applications. These reagents are now offered in bundles with cyclin B2 Antibody (X29.2) (see ordering information below).
QUICK LINKS
Cyclin B2 Antibody (X29.2) is a mouse monoclonal IgG1 antibody that detects cyclin B2 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Cyclin B2 plays a crucial role in the regulation of the cell cycle, particularly during the transition from the G2 phase to mitosis, by forming a complex with the Cdc2 protein kinase, which is essential for the activation of maturation-promoting factor. This complex ensures accurate cell division timing, preventing errors that could lead to conditions such as cancer. Cyclin B2 is primarily located in the cytoplasm during interphase and translocates to the nucleus as cells enter mitosis, highlighting a dynamic role in cell cycle regulation. The precise localization of cyclin B2 allows for timely activation of the Cdc2/cyclin B2 complex, necessary for phosphorylation of target proteins that drive mitotic entry. Cyclin B2′s interaction with other proteins, such as Cdc25 phosphatases, underscores an importance in regulatory networks that control cell division. Anti-cyclin B2 antibody (X29.2) serves as an invaluable tool for researchers studying cell cycle dynamics and molecular mechanisms underlying mitotic regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin B2 Antibody (X29.2) References:
- Cyclin B2 and p53 control proper timing of centrosome separation. | Nam, HJ. and van Deursen, JM. 2014. Nat Cell Biol. 16: 538-49. PMID: 24776885
- The decrease of cyclin B2 expression inhibits invasion and metastasis of bladder cancer. | Lei, CY., et al. 2016. Urol Oncol. 34: 237.e1-10. PMID: 26706119
- Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I. | Li, J., et al. 2018. J Cell Biol. 217: 3901-3911. PMID: 30097513
- Cyclin B2 is required for progression through meiosis in mouse oocytes. | Daldello, EM., et al. 2019. Development. 146: PMID: 30952665
- The cyclin B2/CDK1 complex inhibits separase activity in mouse oocyte meiosis I. | Li, J., et al. 2019. Development. 146: PMID: 31704793
- The Cyclin B2/CDK1 Complex Conservatively Inhibits Separase Activity in Oocyte Meiosis II. | Li, J., et al. 2021. Front Cell Dev Biol. 9: 648053. PMID: 33777955
- Cyclin B2 overexpression promotes tumour growth by regulating jagged 1 in hepatocellular carcinoma. | Xiao, Y., et al. 2022. Aging (Albany NY). 14: 2855-2867. PMID: 35349480
- Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint. | Liu, S., et al. 2022. EMBO Rep. 23: e54171. PMID: 35384228
- Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59/STAT3/Cyclin B2 pathway. | Wei, G., et al. 2022. J Adv Res.. PMID: 36587763
- Prognostic value of cyclin B1 and cyclin B2 expression in breast cancer: A systematic review and updated meta-analysis. | Kang, J., et al. 2024. Medicine (Baltimore). 103: e37016. PMID: 38241547
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin B2 Antibody (X29.2) | sc-53240 | 200 µg/ml | $322.00 | |||
cyclin B2 Antibody (X29.2): m-IgG Fc BP-HRP Bundle | sc-536915 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin B2 Antibody (X29.2): m-IgGκ BP-HRP Bundle | sc-534088 | 200 µg Ab; 40 µg BP | $361.00 | |||
cyclin B2 Antibody (X29.2): m-IgG1 BP-HRP Bundle | sc-544896 | 200 µg Ab; 20 µg BP | $361.00 |