cyclin A Antibody (25): sc-136253
- cyclin A Antibody (25) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against amino acids 26-144 of cyclin A of human origin
- recommended for detection of cyclin A of human origin by WB, IP and IF
- See cyclin A (B-8): sc-271682 for cyclin A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for cyclin A Antibody (25). This work is in progress.
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Cyclin A Antibody (25) is a mouse monoclonal IgG1 antibody that detects cyclin A in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cyclin A plays a pivotal role in the regulation of the eukaryotic cell cycle, particularly during the transition from the S phase to mitosis, making cyclin A essential for proper cell division and proliferation. Cyclin A is primarily located in the nucleus, where cyclin A associates with cyclin-dependent kinases, particularly Cdk2, to facilitate the progression of the cell cycle. The precise localization of cyclin A is crucial, as cyclin A ensures that the kinase activity is regulated at the right time and place within the cell, preventing uncontrolled cell growth that can lead to tumorigenesis. Cyclin A is also known to interact with various proteins, including the retinoblastoma protein and transcription factors such as E2F, which further underscores cyclin A′s importance in cell cycle control and gene expression regulation. Anti-cyclin A antibody (25) is an invaluable tool for researchers studying cell cycle dynamics, cancer biology, and the intricate signaling pathways that govern cellular proliferation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin A Antibody (25) References:
- Degradation of cyclin A is regulated by acetylation. | Mateo, F., et al. 2009. Oncogene. 28: 2654-66. PMID: 19483727
- Cyclin A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1. | Kang, DS., et al. 2012. Biochem Biophys Res Commun. 420: 822-7. PMID: 22465120
- Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. | Kabeche, L. and Compton, DA. 2013. Nature. 502: 110-3. PMID: 24013174
- Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. | Deng, Y., et al. 2014. Bioorg Med Chem Lett. 24: 199-203. PMID: 24332088
- Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication. | Caffarelli, N., et al. 2013. PLoS Pathog. 9: e1003825. PMID: 24385906
- Cyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication. | Copeland, NA., et al. 2015. J Cell Sci. 128: 1518-27. PMID: 25736292
- Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma. | Cyniak-Magierska, A., et al. 2015. Ann Agric Environ Med. 22: 741-6. PMID: 26706989
- Overexpression of cyclin A in oral dysplasia: An international comparison and literature review. | Tandon, R., et al. 2014. Indian J Cancer. 51: 502-5. PMID: 26842177
- Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells. | Niwa, T., et al. 2021. Biochem Biophys Res Commun. 549: 91-97. PMID: 33667714
- Diagnosis of testicular torsion. | Denis, L. 1968. Acta Urol Belg. 36: 425-8. PMID: 5737994
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin A Antibody (25) | sc-136253 | 50 µg/0.5 ml | $322.00 |