CTNNAL1 Antibody (A-4): sc-390854
- CTNNAL1 Antibody (A-4) is a mouse monoclonal IgG2a κ CTNNAL1 antibody provided at 200 µg/ml
- raised against amino acids 46-345 mapping near the N-terminus of CTNNAL1 of human origin
- CTNNAL1 Antibody (A-4) is recommended for detection of CTNNAL1 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-CTNNAL1 Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CTNNAL1 Antibody (A-4) for WB applications. These reagents are now offered in bundles with CTNNAL1 Antibody (A-4) (see ordering information below).
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CTNNAL1 Antibody (A-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects CTNNAL1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CTNNAL1 Antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CTNNAL1, also known as catenin (cadherin-associated protein), alpha-like 1, CLLP, or alpha-CATU, is a 734 amino acid cytoplasmic peripheral membrane protein that belongs to the vinculin/alpha-catenin family. CTNNAL1 is predominantly expressed in the adrenal gland and is found at lower levels in neural tissues, where CTNNAL1 plays a crucial role in the regulation of Rho pathway signaling by serving as a scaffold for the Lbc Rho guanine nucleotide exchange factor 1 (RhoGEF p115). CTNNAL1 influences cellular processes such as migration and proliferation, which are vital for tissue repair and development. CTNNAL1 has been implicated in the down-regulation observed in pancreatic carcinoma during differentiation and apoptosis, highlighting CTNNAL1′s potential role in cancer biology. CTNNAL1 exists in three isoforms produced by alternative splicing, which may further diversify CTNNAL1′s functional roles in cellular contexts, including the wound repair and proliferation of human bronchial epithelial cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CTNNAL1 Antibody (A-4) References:
- Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. | Janssens, B., et al. 1999. Biochim Biophys Acta. 1447: 341-7. PMID: 10542337
- Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. | Park, B., et al. 2002. J Biol Chem. 277: 45361-70. PMID: 12270917
- Distinct activities of the alpha-catenin family, alpha-catulin and alpha-catenin, on beta-catenin-mediated signaling. | Merdek, KD., et al. 2004. Mol Cell Biol. 24: 2410-22. PMID: 14993280
- Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma. | Kupferman, ME., et al. 2007. Oral Oncol. 43: 440-54. PMID: 16978912
- Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1. | Xiang, Y., et al. 2008. J Cell Biochem. 103: 920-30. PMID: 17647259
- Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis. | Wiesner, C., et al. 2008. Oncogene. 27: 2159-69. PMID: 17952117
- Seven placental transcripts characterize HELLP-syndrome. | Buimer, M., et al. 2008. Placenta. 29: 444-53. PMID: 18374411
- Genome-scale identification of UDP-GlcNAc-dependent pathways. | Lau, KS., et al. 2008. Proteomics. 8: 3294-302. PMID: 18646010
- Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. | Zhang, JS., et al. 1998. Genomics. 54: 149-54. PMID: 9806841
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CTNNAL1 Antibody (A-4) | sc-390854 | 200 µg/ml | $322.00 | |||
CTNNAL1 Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-530288 | 200 µg Ab; 10 µg BP | $361.00 | |||
CTNNAL1 Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-523710 | 200 µg Ab, 40 µg BP | $361.00 | |||
CTNNAL1 Antibody (A-4): m-IgG2a BP-HRP Bundle | sc-547473 | 200 µg Ab; 10 µg BP | $361.00 | |||
CTNNAL1 Antibody (A-4) AC | sc-390854 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CTNNAL1 Antibody (A-4) HRP | sc-390854 HRP | 200 µg/ml | $322.00 | |||
CTNNAL1 Antibody (A-4) FITC | sc-390854 FITC | 200 µg/ml | $336.00 | |||
CTNNAL1 Antibody (A-4) PE | sc-390854 PE | 200 µg/ml | $349.00 | |||
CTNNAL1 Antibody (A-4) Alexa Fluor® 488 | sc-390854 AF488 | 200 µg/ml | $364.00 | |||
CTNNAL1 Antibody (A-4) Alexa Fluor® 546 | sc-390854 AF546 | 200 µg/ml | $364.00 | |||
CTNNAL1 Antibody (A-4) Alexa Fluor® 594 | sc-390854 AF594 | 200 µg/ml | $364.00 | |||
CTNNAL1 Antibody (A-4) Alexa Fluor® 647 | sc-390854 AF647 | 200 µg/ml | $364.00 | |||
CTNNAL1 Antibody (A-4) Alexa Fluor® 680 | sc-390854 AF680 | 200 µg/ml | $364.00 | |||
CTNNAL1 Antibody (A-4) Alexa Fluor® 790 | sc-390854 AF790 | 200 µg/ml | $364.00 |