Colivelin (CAS 867021-83-8)
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Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Colivelin suppresses neuronal death by activating STAT3 in vitro. Colivelin protects against β-amyloid neurotoxicity. Colivelin also upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer′s disease (AD) models. Colivelin prevents alcohol-induced apoptosis in a fetal mouse model. Colivelin is considered a brain penetrant. Colivelin is also known as H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH, and L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-proline.
Colivelin (CAS 867021-83-8) References
- Colivelin prolongs survival of an ALS model mouse. | Chiba, T., et al. 2006. Biochem Biophys Res Commun. 343: 793-8. PMID: 16564029
- Neuroprotection against neurodegenerative diseases: development of a novel hybrid neuroprotective peptide Colivelin. | Chiba, T., et al. 2007. Mol Neurobiol. 35: 55-84. PMID: 17519506
- A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. | Sari, Y., et al. 2009. Neuroscience. 164: 1653-64. PMID: 19782727
- Colivelin ameliorates amyloid β peptide-induced impairments in spatial memory, synaptic plasticity, and calcium homeostasis in rats. | Wu, MN., et al. 2015. Hippocampus. 25: 363-72. PMID: 25332198
- New labeled derivatives of the neuroprotective peptide colivelin: synthesis, characterization, and first in vitro and in vivo applications. | Kostomoiri, M., et al. 2015. Arch Biochem Biophys. 567: 83-93. PMID: 25575783
- Protective Effects of Colivelin Against Alzheimer's Disease in a PDAPP Mouse Model. | Yin, R., et al. 2016. Cell Physiol Biochem. 38: 1138-46. PMID: 26964005
- Colivelin Ameliorates Impairments in Cognitive Behaviors and Synaptic Plasticity in APP/PS1 Transgenic Mice. | Wu, M., et al. 2017. J Alzheimers Dis. 59: 1067-1078. PMID: 28731445
- Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. | Zhao, H., et al. 2019. Neuroscience. 416: 198-206. PMID: 31374230
- AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway. | Wang, X., et al. 2021. Mol Med Rep. 24: PMID: 34590152
- PIAS3/SOCS1-STAT3 axis responses to oxidative stress in hepatocellular cancer cells. | Sun, H., et al. 2021. Am J Transl Res. 13: 12395-12409. PMID: 34956461
- SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic differentiation of rat bone marrow mesenchymal stem cells. | Zhang, Y., et al. 2022. Gene. 821: 146190. PMID: 35124149
- GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma. | Gao, H., et al. 2022. Cancer Biol Ther. 23: 369-377. PMID: 35491899
- Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice. | Urban, C., et al. 2022. Front Immunol. 13: 984298. PMID: 36119052
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Colivelin, 1 mg | sc-361153 | 1 mg | $612.00 |