Clathrin Heavy Chain/CLTC Antibody (STo 3H9): sc-53225
- Clathrin Heavy Chain/CLTC Antibody (STo 3H9) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against Clathrin heavy chain of human origin
- recommended for detection of Clathrin HC of human origin by WB, IP, IF and IHC(P)
- See Clathrin Heavy Chain/CLTC (TD.1): sc-12734 for Clathrin Heavy Chain/CLTC antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Clathrin Heavy Chain/CLTC Antibody (STo 3H9) for WB and IHC(P) applications. This reagent is now offered in a bundle with Clathrin Heavy Chain/CLTC Antibody (STo 3H9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Clathrin HC Antibody (STo 3H9) is a mouse monoclonal IgM antibody that detects Clathrin HC in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Clathrin HC antibody (STo 3H9) plays a crucial role in studying endocytosis, where Clathrin HC forms a protective coat around vesicles that transport proteins and lipids into the cell. Clathrin HC (STo 3H9) monoclonal antibody recognizes this protein primarily in the cytoplasm, where Clathrin HC is essential for forming clathrin-coated vesicles, which are vital for membrane receptor internalization and cellular signaling pathway regulation. Clathrin HC′s interaction with various adaptor proteins and membrane receptors underscores its importance in maintaining cellular homeostasis and facilitating communication between cell surface and intracellular compartments. Anti-Clathrin HC antibody (STo 3H9) serves as an invaluable tool for researchers studying endocytic pathways and their implications in various physiological and pathological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Clathrin Heavy Chain/CLTC Antibody (STo 3H9) References:
- Controlled elimination of clathrin heavy-chain expression in DT40 lymphocytes. | Wettey, FR., et al. 2002. Science. 297: 1521-5. PMID: 12202821
- IL-7 induces tyrosine phosphorylation of clathrin heavy chain. | Jiang, Q., et al. 2004. Cell Signal. 16: 281-6. PMID: 14636898
- Clathrin heavy chain is required for pinocytosis, the presence of large vacuoles, and development in Dictyostelium. | O'Halloran, TJ. and Anderson, RG. 1992. J Cell Biol. 118: 1371-7. PMID: 1522112
- Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization. | Vassilopoulos, S., et al. 2014. J Cell Biol. 205: 377-93. PMID: 24798732
- Transformation by Rous sarcoma virus induces clathrin heavy chain phosphorylation. | Martin-Perez, J., et al. 1989. J Cell Biol. 109: 577-84. PMID: 2547803
- Clathrin Heavy Chain Interacts With Estrogen Receptor α and Modulates 17β-Estradiol Signaling. | Totta, P., et al. 2015. Mol Endocrinol. 29: 739-55. PMID: 25860340
- Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain. | Boettner, DR., et al. 2016. Traffic. 17: 754-68. PMID: 27062026
- Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development. | Nahorski, MS., et al. 2018. Sci Rep. 8: 2340. PMID: 29402896
- Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. | Dejonghe, W., et al. 2019. Nat Chem Biol. 15: 641-649. PMID: 31011214
- Clathrin heavy chain: molecular cloning and complete primary structure. | Kirchhausen, T., et al. 1987. Proc Natl Acad Sci U S A. 84: 8805-9. PMID: 3480512
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clathrin Heavy Chain/CLTC Antibody (STo 3H9) | sc-53225 | 200 µg/ml | $322.00 | |||
Clathrin Heavy Chain/CLTC Antibody (STo 3H9): m-IgGκ BP-HRP Bundle | sc-552781 | 200 µg Ab; 40 µg BP | $361.00 |